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Anti-CDC16 Antibody

品牌：Antibodies

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规格：100µl

货期：

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Anti-CDC16 Antibody

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Name:	Anti-CDC16 Antibody See all CDC16 primary antibodies
Description:	Rabbit polyclonal antibody to CDC16
Specificity:	The antibody detects endogenous levels of total CDC16 protein.
Applications:	WB, IHC
Reactivity:	Human
Immunogen:	Synthetic peptide corresponding to residues near the N terminal of human cell division cycle 16
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	Antigen affinity purification.
Concentration:	2.9mg / ml
Formulation:	Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
Storage:	Store at -20?C

Function:	Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.
Sequence Similarities:	Belongs to the APC6/CDC16 family.
Post-Translational Modification:	Phosphorylated. Phosphorylation on Ser-560 occurs specifically during mitosis.
Cellular Location:	Cytoplasm > Cytoskeleton > Microtubule organizing center > Centrosome. Cytoplasm > Cytoskeleton > Spindle. Colocalizes with CDC27 to the centrosome at all stages of the cell cycle and to the mitotic spindle.