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Anti-CD79B Antibody

品牌：Antibodies

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规格：100µl

货期：

应用：

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Anti-CD79B Antibody

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Overview

Name:	Anti-CD79B Antibody See all CD79B primary antibodies
Description:	Rabbit polyclonal antibody to CD79B
Specificity:	The antibody detects endogenous level of total CD79B protein.
Applications:	WB, IHC, IF
Reactivity:	Human, Mouse, Rat
Immunogen:	Recombinant protein of human CD79B.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	Antibodies were purified by affinity purification using immunogen.
Concentration:	1.0mg / ml
Formulation:	Supplied at 1.0mg / mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage:	Store at -20?C

Target

Function:	Required in cooperation with CD79A for initiation of the signal transduction cascade activated by the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Enhances phosphorylation of CD79A, possibly by recruiting kinases which phosphorylate CD79A or by recruiting proteins which bind to CD79A and protect it from dephosphorylation.
Tissue Specificity:	B-cells.
Involvement in Disease:	Agammaglobulinemia 6, autosomal recessive: A primary immunodeficiency characterized by profoundly low or absent serum antibodies and low or absent circulating B-cells due to an early block of B-cell development. Affected individuals develop severe infections in the first years of life.
Post-Translational Modification:	Phosphorylated on tyrosine upon B-cell activation by SRC-type Tyr-kinases such as BLK, LYN and SYK.
Cellular Location:	Cell membrane. Following antigen binding, the BCR has been shown to translocate from detergent-soluble regions of the cell membrane to lipid rafts although signal transduction through the complex can also occur outside lipid rafts.
Database Links:	Entrez Gene: 974?Human Entrez Gene: 15985?Mouse Entrez Gene: 171055?Rat Omim: 147245?Human SwissProt: P40259?Human SwissProt: P15530?Mouse Unigene: 89575?Human Unigene: 2987?Mouse Unigene: 62607?Rat
Synonyms:	AGM6 Antibody B cell antigen receptor complex associated protein beta chain Antibody B cell specific glycoprotein B29 Antibody B-cell antigen receptor complex-associated protein beta chain Antibody B-cell-specific glycoprotein B29 Antibody B29 Antibody B29/Ig-beta/CD79b Antibody CD 79b Antibody CD79b Antibody CD79b antigen Antibody CD79b antigen (immunoglobulin associated beta) Antibody CD79b molecule Antibody CD79b molecule immunoglobulin associated beta Antibody CD79b protein Antibody CD79B_HUMAN Antibody Ig beta Antibody Ig-beta Antibody IGB Antibody Igbeta Antibody Immunoglobulin associated B29 Antibody Immunoglobulin associated B29 protein Antibody Immunoglobulin associated beta Antibody Immunoglobulin associated protein Antibody Immunoglobulin-associated B29 protein Antibody MGC108607 Antibody
Information:	Target information shown above is from the UniProt Consortium.