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Anti-CD5L Antibody

品牌：Antibodies

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规格：100µl

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Anti-CD5L Antibody

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Overview

Name:	Anti-CD5L Antibody See all CD5L primary antibodies
Description:	Rabbit polyclonal antibody to CD5L
Specificity:	The antibody detects endogenous levels of total CD5L protein.
Applications:	IHC
Reactivity:	Human
Immunogen:	Synthetic peptide corresponding to residues near the C terminal of human CD5 molecule-like
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	Antigen affinity purification.
Concentration:	1.9mg / ml
Formulation:	Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
Storage:	Store at -20?C

Target

Function:	Secreted protein that acts as a key regulator of lipid synthesis: mainly expressed by macrophages in lymphoid and inflammed tissues and regulates mechanisms in inflammatory responses, such as infection or atherosclerosis. Able to inhibit lipid droplet size in adipocytes. Following incorporation into mature adipocytes via CD36-mediated endocytosis, associates with cytosolic FASN, inhibiting fatty acid synthase activity and leading to lipolysis, the degradation of triacylglycerols into glycerol and free fatty acids (FFA). CD5L-induced lipolysis occurs with progression of obesity: participates in obesity-associated inflammation following recruitment of inflammatory macrophages into adipose tissues, a cause of insulin resistance and obesity-related metabolic disease. Regulation of intracellular lipids mediated by CD5L has a direct effect on transcription regulation mediated by nuclear receptors ROR-gamma (RORC). Acts as a key regulator of metabolic switch in T-helper Th17 cells. Regulates the expression of pro-inflammatory genes in Th17 cells by altering the lipid content and limiting synthesis of cholesterol ligand of RORC, the master transcription factor of Th17-cell differentiation. CD5L is mainly present in non-pathogenic Th17 cells, where it decreases the content of polyunsaturated fatty acyls (PUFA), affecting two metabolic proteins MSMO1 and CYP51A1, which synthesize ligands of RORC, limiting RORC activity and expression of pro-inflammatory genes. Participates in obesity-associated autoimmunity via its association with IgM, interfering with the binding of IgM to Fcalpha/mu receptor and enhancing the development of long-lived plasma cells that produce high-affinity IgG autoantibodies (By similarity). Also acts as an inhibitor of apoptosis in macrophages: promotes macrophage survival from the apoptotic effects of oxidized lipids in case of atherosclerosis (PubMed:24295828). Involved in early response to microbial infection against various pathogens by acting as a pattern recognition receptor and by promoting autophagy (PubMed:16030018, PubMed:24223991, PubMed:24583716, PubMed:25713983).
Tissue Specificity:	Expressed in spleen, lymph node, thymus, bone marrow, and fetal liver, but not in non-lymphoid tissues.
Post-Translational Modification:	Not N-glycosylated (PubMed:23236605). Probably not O-glycosylated (PubMed:23236605).
Cellular Location:	Secreted. Cytoplasm. Secreted by macrophages and circulates in the blood (PubMed:24223991, PubMed:24804991). Transported in the cytoplasm via CD36-mediated endocytosis (By similarity).
Database Links:	Entrez Gene: 922?Human Omim: 602592?Human SwissProt: O43866?Human Unigene: 134035?Human
Synonyms:	AAC-11 Antibody AIM Antibody API6 Antibody APOPTOSIS INHIBITOR 6 Antibody APOPTOSIS INHIBITOR OF MACROPHAGES Antibody CD5 antigen like (scavenger receptor cysteine rich family) Antibody CD5 antigen-like Antibody CD5L Antibody CD5L_HUMAN Antibody CT 2 Antibody CT-2 Antibody Highly similar to ANTIGEN WC1.1 [Bos taurus] Antibody IgM associated peptide Antibody IgM-associated peptide Antibody Pdp Antibody PRO229 Antibody SCAVENGER RECEPTOR CYSTEINE-RICH FAMILY Antibody SP ALPHA Antibody SP-alpha Antibody Spalpha Antibody
Information:	Target information shown above is from the UniProt Consortium.