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Anti-CD42b Antibody

品牌：Antibodies

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规格：100T

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Anti-CD42b Antibody

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Overview

Name:	Anti-CD42b Antibody See all CD42b primary antibodies
Description:	Mouse monoclonal (AK2) antibody to CD42b (FITC).
Specificity:	The mouse monoclonal antibody AK2 recognizes CD42b (GPIb alpha), a 135-145 kDa membrane glycoprotein expressed on platelets and megakaryocytes. CD42b and CD42c (GPIb beta) are composed in a disulfide linked heterodimer (CD42b/c; 160 kDa); CD42b/c forms a noncovalent complex with CD42a and CD42d.
Applications:	FC, IP, WB, ICC, ELISA
Reactivity:	Human
Immunogen:	Human platelets.
Host:	Mouse
Clonality:	Monoclonal
Clone:	AK2
Isotype:	IgG1
Conjugate:	FITC
Product Form:	Liquid
Formulation:	Supplied in Phosphate Buffered Saline with 15mM Sodium Azide.
Storage:	Store in the dark at 2-8°C. Avoid prolonged exposure to light.

Target

Function:	GP-Ib, a surface membrane protein of platelets, participates in the formation of platelet plugs by binding to the A1 domain of vWF, which is already bound to the subendothelium.
Involvement in Disease:	Non-arteritic anterior ischemic optic neuropathy: An ocular disease due to ischemic injury to the optic nerve. It usually affects the optic disk and leads to visual loss and optic disk swelling of a pallid nature. Visual loss is usually sudden, or over a few days at most and is usually permanent, with some recovery possibly occurring within the first weeks or months. Patients with small disks having smaller or non-existent cups have an anatomical predisposition for non-arteritic anterior ischemic optic neuropathy. As an ischemic episode evolves, the swelling compromises circulation, with a spiral of ischemia resulting in further neuronal damage. Bernard-Soulier syndrome: A coagulation disorder characterized by a prolonged bleeding time, unusually large platelets, thrombocytopenia, and impaired prothrombin consumption. Bernard-Soulier syndrome A2, autosomal dominant: A coagulation disorder characterized by mild to moderate bleeding tendency, thrombocytopenia, and an increased mean platelet volume. Some individuals have no symptoms. Mild bleeding tendencies manifest as epistaxis, gingival bleeding, menorrhagia, easy bruising, or prolonged bleeding after dental surgery. Pseudo-von Willebrand disease: A bleeding disorder characterized by abnormally enhanced binding of von Willebrand factor by the platelet glycoprotein Ib (GP Ib) receptor complex. Hemostatic function is impaired due to the removal of VWF multimers from the circulation.
Post-Translational Modification:	Glycocalicin, which is approximately coextensive with the extracellular part of the molecule, is cleaved off by calpain during platelet lysis.
Cellular Location:	Membrane.
Database Links:	Entrez Gene: 2811 Human Omim: 606672 Human SwissProt: P07359 Human Unigene: 1472 Human
Synonyms:	Antigen CD42b alpha Antibody BDPLT1 Antibody BDPLT3 Antibody BSS Antibody CD 42b Antibody CD42b Antibody CD42b alpha Antibody CD42b antigen Antibody DBPLT3 Antibody GLYCOCALICIN Antibody Glycoprotein Ib (platelet) alpha polypeptide Antibody Glycoprotein Ibalpha Antibody GP Ib alpha Antibody GP1B Antibody GP1BA Antibody GPIb alpha Antibody GPIbA Antibody MGC34595 Antibody Platelet glycoprotein Ib alpha chain Antibody Platelet glycoprotein Ib alpha polypeptide Antibody Platelet membrane glycoprotein 1b alpha subunit Antibody VWDP Antibody
Information:	Target information shown above is from the UniProt Consortium.