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Anti-CD41 Antibody

品牌：Antibodies

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规格：100µg

货期：

应用：

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Anti-CD41 Antibody

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Overview

Name:	Anti-CD41 Antibody See all CD41 primary antibodies
Description:	Mouse monoclonal (MEM-06) antibody to CD41 (Biotin).
Specificity:	The antibody MEM-06 reacts with CD41 (GPIIb), a transmembrane glycoprotein (integrin family) composed of two chains GPIIb alpha (heavy chain; 120 kDa) and GPIIb beta (light chain; 23 kDa). CD41 is mainly expressed on platelets and megakaryocytes.
Applications:	FC
Reactivity:	Human
Immunogen:	Leukocytes from a patient suffering from a LGL Type leukemia.
Host:	Mouse
Clonality:	Monoclonal
Clone:	MEM-06
Isotype:	IgG1
Conjugate:	Biotin
Concentration:	1 mg/ml
Product Form:	Liquid
Formulation:	Supplied in Phosphate Buffered Saline, pH 7.4, with 15mM Sodium Azide.
Storage:	Store at 2-8°C.

Target

Function:	Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface.
Tissue Specificity:	Isoform 1 and isoform 2 were identified in platelets and megakaryocytes, but not in reticulocytes or in Jurkat and U-937 white blood cell line. Isoform 3 is expressed by leukemia, prostate adenocarcinoma and melanoma cells but not by platelets or normal prostate or breast epithelial cells.
Involvement in Disease:	Glanzmann thrombasthenia: A common inherited disease of platelet aggregation. It is characterized by mucocutaneous bleeding of mild-to-moderate severity. GT has been classified clinically into types I and II. In type I, platelets show absence of the glycoprotein IIb-IIIa complexes at their surface and lack fibrinogen and clot retraction capability. In type II, the platelets express the GPIIb-IIIa complex at reduced levels, have detectable amounts of fibrinogen, and have low or moderate clot retraction capability. Bleeding disorder, platelet-type 16: An autosomal dominant form of congenital macrothrombocytopenia associated with platelet anisocytosis. It is a disorder of platelet production. Affected individuals may have no or only mildly increased bleeding tendency. In vitro studies show mild platelet functional abnormalities.
Sequence Similarities:	Belongs to the integrin alpha chain family.
Cellular Location:	Membrane.
Database Links:	Entrez Gene: 3674 Human Omim: 607759 Human SwissProt: P08514 Human Unigene: 411312 Human
Synonyms:	antigen CD41 Antibody BDPLT16 Antibody BDPLT2 Antibody CD41 Antibody CD41B Antibody form 2 Antibody GP2B Antibody GPalpha IIb Antibody GPIIb Antibody GT Antibody GTA Antibody HPA3 Antibody Integrin alpha 2b Antibody Integrin alpha IIb Antibody Integrin alpha-IIb light chain Antibody Integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41) Antibody ITA2B_HUMAN Antibody Itga2b Antibody ITGAB Antibody platelet fibrinogen receptor, alpha subunit Antibody platelet glycoprotein IIb of IIb/IIIa complex Antibody Platelet membrane glycoprotein IIb Antibody platelet specific antigen BAK Antibody PPP1R93 Antibody
Information:	Target information shown above is from the UniProt Consortium.