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Anti-CD40LG Antibody

品牌：Antibodies

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规格：50µl

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Anti-CD40LG Antibody

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Overview

Name:	Anti-CD40LG Antibody See all CD40LG primary antibodies
Description:	Rabbit polyclonal antibody to CD40LG.
Applications:	WB, IHC, IF
Dilutions:	WB: 1:500 - 1:2000, IHC: 1:50 - 1:200, IF: 1:50 - 1:200.
Reactivity:	Human
Immunogen:	Recombinant protein of human CD40LG.
Protein Length:	261
Host:	Rabbit
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Unconjugated
Purification:	Affinity purification.
Product Form:	Liquid
Formulation:	Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage:	Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Target

Function:	Cytokine that binds to CD40/TNFRSF5 (PubMed:1280226). Costimulates T-cell proliferation and cytokine production. Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation (PubMed:8617933). Induces the activation of NF-kappa-B and kinases MAPK8 and PAK2 in T-cells. Induces tyrosine phosphorylation of isoform 3 of CD28 (PubMed:15067037). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of IL4. Involved in immunoglobulin class switching (By similarity).
Tissue Specificity:	Specifically expressed on activated CD4+ T-lymphocytes.
Involvement in Disease:	X-linked immunodeficiency with hyper-IgM 1: Immunoglobulin isotype switch defect characterized by elevated concentrations of serum IgM and decreased amounts of all other isotypes. Affected males present at an early age (usually within the first year of life) recurrent bacterial and opportunistic infections, including Pneumocystis carinii pneumonia and intractable diarrhea due to cryptosporidium infection. Despite substitution treatment with intravenous immunoglobulin, the overall prognosis is rather poor, with a death rate of about 10% before adolescence.
Sequence Similarities:	Belongs to the tumor necrosis factor family.
Post-Translational Modification:	The soluble form derives from the membrane form by proteolytic processing.
Cellular Location:	Cell membrane. Cell surface.
Database Links:	Entrez Gene: 959?Human Omim: 300386?Human SwissProt: P29965?Human Unigene: 592244?Human
Synonyms:	CD 40L Antibody CD154 Antibody CD40 antigen ligand Antibody CD40 ligand Antibody CD40 ligand, soluble form Antibody CD40-L Antibody CD40L Antibody CD40LG Antibody CD40L_HUMAN Antibody gp39 Antibody hCD40L Antibody HIGM1 Antibody IGM Antibody IMD3 Antibody soluble form Antibody T B cell activating molecule Antibody T BAM Antibody T cell antigen Gp39 Antibody T-cell antigen Gp39 Antibody TNF related activation protein Antibody TNF-related activation protein Antibody TNFSF5 Antibody TrAP Antibody Tumor necrosis factor (ligand) superfamily member 5 Antibody Tumor necrosis factor (ligand) superfamily, member 5 (hyper-IgM syndrome) Antibody Tumor necrosis factor ligand superfamily member 5 Antibody
Information:	Target information shown above is from the UniProt Consortium.