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Anti-CD305 Antibody

品牌：Antibodies

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规格：50µl

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Anti-CD305 Antibody

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Overview

Name:	Anti-CD305 Antibody See all CD305 primary antibodies
Description:	Rabbit polyclonal antibody to CD305
Specificity:	CD305 Polyclonal Antibody detects endogenous levels of CD305 protein.
Applications:	WB, ELISA
Reactivity:	Human
Immunogen:	Synthesized peptide derived from the Internal region of human CD305.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:	1mg / ml
Formulation:	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Storage:	Store at -20˚C / 1 year

Target

Function:	Functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation. May also play its inhibitory role independently of SH2-containing phosphatases. Modulates cytokine production in CD4+ T-cells, down-regulating IL2 and IFNG production while inducing secretion of transforming growth factor beta. Down-regulates also IgG and IgE production in B-cells as well as IL8, IL10 and TNF secretion. Inhibits proliferation and induces apoptosis in myeloid leukemia cell lines as well as prevents nuclear translocation of NF-kappa-B p65 subunit/RELA and phosphorylation of I-kappa-B alpha/CHUK in these cells. Inhibits the differentiation of peripheral blood precursors towards dendritic cells.
Tissue Specificity:	Expressed on the majority of peripheral mononuclear cells, including natural killer (NK) cells, T-cells, B-cells, monocytes, and dendritic cells. Highly expressed in naive T-cells and B-cells but no expression on germinal center B-cells. Abnormally low expression in naive B-cells from HIV-1 infected patients. Very low expression in NK cells from a patient with chronic active Epstein-Barr virus infection.
Post-Translational Modification:	Phosphorylation at Tyr-251 and Tyr-281 activates it. May be phosphorylated by LCK.
Cellular Location:	Cell membrane.
Database Links:	Entrez Gene: 3903 Human Omim: 602992 Human SwissProt: Q6GTX8 Human Unigene: 572535 Human
Synonyms:	5133400O11Rik Antibody CD305 Antibody D7Bwg0421e Antibody hLAIR1 Antibody LAIR 1 Antibody LAIR-1 Antibody LAIR1 Antibody LAIR1 protein Antibody LAIR1_HUMAN Antibody Leukocyte associated Ig like receptor 1 Antibody Leukocyte associated immunoglobulin like receptor 1 Antibody Leukocyte-associated immunoglobulin-like receptor 1 Antibody
Information:	Target information shown above is from the UniProt Consortium.