Anti-CD2AP Antibody |产品详情|进口试剂采购网

您好，欢迎来到拜力生物网站！请登录注册

我的订单 | 联系我们 | 在线客服QQ：3012681483 | 客服电话：400-968-7988 | 工作时间：08:30-17:30

主营产品： ELISA试剂盒、抗体、补体血清、兔补体、干扰素、小鼠测温仪、进口试剂、Quidel代理、Swant代理、PBL Assay Science代理

网站首页产品中心代理品牌新闻资讯资源中心关于我们

所在位置：首页 > 产品中心 > Antibodies > Antibodies产品

订购信息

上海拜力生物科技公司

Tel:400-968-7988 021-33779008

Anti-CD2AP Antibody

品牌：Antibodies

货号：

规格：100µl

货期：

应用：

咨询客服

立即购买加入购物车

Anti-CD2AP Antibody

商品详情参考文献相关资料

Overview

Name:	Anti-CD2AP Antibody See all CD2AP primary antibodies
Description:	Rabbit polyclonal antibody to CD2AP
Specificity:	The antibody detects endogenous levels of total CD2AP protein.
Applications:	WB, IHC
Reactivity:	Human
Immunogen:	Synthetic peptide corresponding to a region derived from internal residues of human CD2-associated protein
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	Antigen affinity purification.
Concentration:	3mg / ml
Formulation:	Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
Storage:	Store at -20?C

Target

Function:	Seems to act as an adapter protein between membrane proteins and the actin cytoskeleton. In collaboration with CBLC, modulates the rate of RET turnover and may act as regulatory checkpoint that limits the potency of GDNF on neuronal survival. Controls CBLC function, converting it from an inhibitor to a promoter of RET degradation. May play a role in receptor clustering and cytoskeletal polarity in the junction between T-cell and antigen-presenting cell. May anchor the podocyte slit diaphragm to the actin cytoskeleton in renal glomerolus. Also required for cytokinesis.
Tissue Specificity:	Widely expressed in fetal and ***** tissues.
Involvement in Disease:	Focal segmental glomerulosclerosis 3: A renal pathology defined by the presence of segmental sclerosis in glomeruli and resulting in proteinuria, reduced glomerular filtration rate and progressive decline in renal function. Renal insufficiency often progresses to end-stage renal disease, a highly morbid state requiring either dialysis therapy or kidney transplantation.
Post-Translational Modification:	Phosphorylated on tyrosine residues; probably by c-Abl, Fyn and c-Src.
Cellular Location:	Cytoplasm > Cytoskeleton. Cell projection > Ruffle. Colocalizes with F-actin and BCAR1/p130Cas in membrane ruffles. Located at podocyte slit diaphragm between podocyte foot processes (By similarity). During late anaphase and telophase, concentrates in the vicinity of the midzone microtubules and in the midbody in late telophase.
Database Links:	Entrez Gene: 23607?Human Omim: 604241?Human SwissProt: Q9Y5K6?Human Unigene: 485518?Human
Synonyms:	Adapter protein CMS Antibody AL024079 Antibody C78928 Antibody Cas ligand with multiple SH3 domains Antibody CD2 associated protein Antibody CD2-associated protein Antibody CD2AP Antibody CD2AP_HUMAN Antibody CMS Antibody Mesenchyme to epithelium transition protein with SH3 domains 1 Antibody METS 1 Antibody Mets1 Antibody
Information:	Target information shown above is from the UniProt Consortium.