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Anti-CD261 Antibody

品牌：Antibodies

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规格：100µg

货期：

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Anti-CD261 Antibody

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Name:	Anti-CD261 Antibody See all DR4 primary antibodies
Description:	Mouse monoclonal (DR-4-02) antibody to CD261.
Specificity:	The antibody DR-4-02 recognizes TRAIL-R1 (DR4), a human death receptor 4 (468 amino acids) expressed in most human tissues (spleen, peripheral blood leucocytes, thymus) and in a variety of tumour-derived cell lines.
Applications:	FC, IP, ICC, FUNC
Reactivity:	Human
Immunogen:	Fusion protein containing the extracellular part of TRAIL-R1 and the constant part of the heavy chain of the human IgG1.
Host:	Mouse
Clonality:	Monoclonal
Clone:	DR-4-02
Isotype:	IgG1
Conjugate:	Unconjugated
Purification:	Protein A chromatography.
Concentration:	1 mg/ml
Purity:	> 95% (by SDS-PAGE)
Product Form:	Liquid
Formulation:	Supplied in Phosphate Buffered Saline, pH 7.4, with 15mM Sodium Azide.
Storage:	Store at 2-8°C.

Function:	Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B.
Tissue Specificity:	Widely expressed. High levels are found in spleen, peripheral blood leukocytes, small intestine and thymus, but also in K-562 erythroleukemia cells, MCF-7 breast carcinoma cells and activated T-cells.
Cellular Location:	Membrane.
Database Links:	Entrez Gene: 8797 Human Omim: 603611 Human SwissProt: O00220 Human Unigene: 213467 Human Unigene: 591834 Human
Synonyms:	Apo2 Antibody CD261 Antibody Cytotoxic TRAIL receptor Antibody Death receptor 4 Antibody DR4 Antibody NF related apoptosis-inducing ligand receptor 1 Antibody TNF receptor superfamily member 10a Antibody TNF-related apoptosis-inducing ligand receptor 1 Antibody TNFRSF10A Antibody TR10A_HUMAN Antibody TRAIL receptor 1 Antibody TRAIL-R1 Antibody TRAILR 1 Antibody TRAILR1 Antibody Tumor necrosis factor receptor superfamily member 10A Antibody Tumor necrosis factor receptor superfamily member 10a variant 2 Antibody Tumor necrosis factor receptor superfamily, member 10a Antibody
Information:	Target information shown above is from the UniProt Consortium.