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Anti-CD22 Antibody

品牌：Antibodies

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规格：100T

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Anti-CD22 Antibody

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Overview

Name:	Anti-CD22 Antibody See all CD22 primary antibodies
Description:	Mouse monoclonal (IS7) antibody to CD22 (PE).
Specificity:	The antibody IS7 reacts with CD22 (BL-CAM), a 130 kDa type I transmembrane glycoprotein (immunoglobulin superfamily) expressed in the cytoplasm of pro-B and pre-B lymphocytes, and on the surface of mature and activated B lymphocytes; it is lost on plasma cells, peripheral blood T lymphocytes, granulocytes and monocytes.
Applications:	FC
Reactivity:	Human
Immunogen:	Human cell line Reh.
Host:	Mouse
Clonality:	Monoclonal
Clone:	IS7
Isotype:	IgG1
Conjugate:	PE
Purification:	Size exclusion chromatography.
Product Form:	Liquid
Formulation:	Supplied in Phosphate Buffered Saline with 15mM Sodium Azide.
Storage:	Store in the dark at 2-8°C. Avoid prolonged exposure to light.

Target

Function:	Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. Upon ligand induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules.
Tissue Specificity:	B-lymphocytes.
Sequence Similarities:	Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.
Post-Translational Modification:	Phosphorylation of Tyr-762, Tyr-807 and Tyr-822 are involved in binding to SYK, GRB2 and SYK, respectively. Phosphorylation of Tyr-842 is involved in binding to SYK, PLCG2 and PIK3R1/PIK3R2.
Cellular Location:	Cell membrane.
Database Links:	Entrez Gene: 933 Human Omim: 107266 Human SwissProt: P20273 Human Unigene: 579691 Human
Synonyms:	B cell receptor CD22 precursor Antibody B lymphocyte cell adhesion molecule Antibody B-cell receptor CD22 Antibody B-lymphocyte cell adhesion molecule Antibody BL CAM Antibody BL-CAM Antibody BLCAM Antibody CD 22 Antibody CD22 Antibody CD22 antigen Antibody CD22 molecule Antibody CD22 protein Antibody CD22_HUMAN Antibody Lectin 2 Antibody Leu14 Antibody Lyb8 Antibody MGC130020 Antibody sialic acid binding Ig like lectin 2 Antibody Sialic acid binding immunoglobulin like lectin 2 Antibody Sialic acid-binding Ig-like lectin 2 Antibody SIGLEC 2 Antibody Siglec-2 Antibody SIGLEC2 Antibody T cell surface antigen Leu 14 Antibody T-cell surface antigen Leu-14 Antibody
Information:	Target information shown above is from the UniProt Consortium.