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Anti-CD10 Antibody

品牌：Antibodies

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规格：100T

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Anti-CD10 Antibody

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Overview

Name:	Anti-CD10 Antibody See all CD10 primary antibodies
Description:	Rabbit monoclonal (K16-P) antibody to CD10 (FITC).
Applications:	FC
Dilutions:	10 μl per test.
Reactivity:	Human
Host:	Rabbit
Clonality:	Monoclonal
Clone:	K16-P
Isotype:	IgG
Conjugate:	FITC
Product Form:	Liquid
Formulation:	Supplied in Aqueous Buffer Solution with 10mg/ml BSA & 0.05% Sodium Azide.
Storage:	Store undiluted at 4°C, protect from prolonged exposure to light. Do not freeze.

Target

Function:	Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids (PubMed:15283675, PubMed:8168535). Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond (PubMed:17101991). Able to cleave angiotensin-1, angiotensin-2 and angiotensin 1-9 (PubMed:15283675). Involved in the degradation of atrial natriuretic factor (ANF) (PubMed:2531377, PubMed:2972276). Displays UV-inducible elastase activity toward skin preelastic and elastic fibers (PubMed:20876573).
Involvement in Disease:	Charcot-Marie-Tooth disease 2T: An axonal form of Charcot-Marie-Tooth disease, a disorder of the peripheral nervous system, characterized by progressive weakness and atrophy, initially of the peroneal muscles and later of the distal muscles of the arms. Charcot-Marie-Tooth disease is classified in two main groups on the basis of electrophysiologic properties and histopathology: primary peripheral demyelinating neuropathies (designated CMT1 when they are dominantly inherited) and primary peripheral axonal neuropathies (CMT2). Neuropathies of the CMT2 group are characterized by signs of axonal degeneration in the absence of obvious myelin alterations, normal or slightly reduced nerve conduction velocities, and progressive distal muscle weakness and atrophy. Spinocerebellar ataxia 43: A form of spinocerebellar ataxia, a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA43 is a slowly progressive, autosomal dominant form.
Sequence Similarities:	Belongs to the peptidase M13 family.
Post-Translational Modification:	Myristoylation is a determinant of membrane targeting.
Cellular Location:	Cell membrane.
Database Links:	Entrez Gene: 4311 Human Omim: 120520 Human SwissProt: P08473 Human Unigene: 307734 Human
Synonyms:	Atriopeptidase Antibody CALLA Antibody CD10 Antibody CD10 antigen Antibody Common acute lymphocytic leukemia antigen Antibody DKFZp686O16152 Antibody EC 3.4.24.11 Antibody Enkephalinase Antibody EPN Antibody Membrane metallo endopeptidase Antibody Membrane metallo endopeptidase (neutral endopeptidase, enkephalinase) Antibody Membrane metallo endopeptidase (neutral endopeptidase, enkephalinase, CALLA, CD10) Antibody Membrane metallo endopeptidase variant 1 Antibody Membrane metallo endopeptidase variant 2 Antibody Membrane metalloendopeptidase Antibody Membrane metalloendopeptidase neutral endopeptidase enkephalinase Antibody Membrane metalloendopeptidase neutral endopeptidase enkephalinase CALLA CD10 Antibody Membrane metalloendopeptidase variant 1 Antibody Membrane metalloendopeptidase variant 2 Antibody MGC126681 Antibody MGC126707 Antibody MME Antibody NEP Antibody Neprilysin Antibody neprilysin-390 Antibody neprilysin-411 Antibody NEP_HUMAN Antibody Neutral endopeptidase Antibody Neutral endopeptidase 24.11 Antibody Neutral endopeptidase, membrane-associated Antibody SFE Antibody Skin fibroblast elastase Antibody
Information:	Target information shown above is from the UniProt Consortium.