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Anti-CCNF Antibody

品牌：Antibodies

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规格：100µl

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Anti-CCNF Antibody

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Name:	Anti-CCNF Antibody See all CCNF primary antibodies
Description:	Rabbit polyclonal antibody to CCNF
Specificity:	The antibody detects endogenous levels of total CCNF protein.
Applications:	WB, IHC
Reactivity:	Human
Immunogen:	Fusion protein corresponding to residues near the C terminal of human cyclin F
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	Antigen affinity purification.
Concentration:	1.1mg / ml
Formulation:	Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
Storage:	Store at -20?C

Function:	Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of CP110 during G2 phase, thereby acting as an inhibitor of centrosome reduplication.
Tissue Specificity:	Widely expressed.
Sequence Similarities:	Belongs to the cyclin family. Cyclin AB subfamily.
Post-Translational Modification:	Degraded when the spindle assembly checkpoint is activated during the G2-M transition. Degradation is not dependent on the proteasome or ubiquitin and depends on the C-terminal PEST sequence.
Cellular Location:	Nucleus. Cytoplasm > Cytoskeleton > Microtubule organizing center > Centrosome > Centriole. Localization in the centrosome is rare in S phase cells and increases in G2 cells, Localizes on both the mother and daughter centrioles. Localization to centrosomes is not dependent on CP110. Also localizes to the nucleus.
Database Links:	Entrez Gene: 899?Human Omim: 600227?Human SwissProt: P41002?Human Unigene: 1973?Human
Synonyms:	Ccnf Antibody CCNF_HUMAN Antibody Cyclin F Antibody Cyclin-F Antibody F box only protein 1 Antibody F-box only protein 1 Antibody FBX1 Antibody FBXO1 Antibody G2 mitotic specific cyclin F Antibody G2/mitotic specific cyclin F Antibody
Information:	Target information shown above is from the UniProt Consortium.