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Anti-CCND2 Antibody

品牌：Antibodies

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规格：100µl

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Anti-CCND2 Antibody

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Overview

Name:	Anti-CCND2 Antibody See all CCND2 primary antibodies
Description:	Rabbit polyclonal antibody to CCND2
Specificity:	The antibody detects endogenous level of total CCND2 antibody.
Applications:	WB, IF
Reactivity:	Human, Mouse, Rat
Immunogen:	Recombinant Protein of human CCND2.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	Antibodies were purified by affinity purification using immunogen.
Concentration:	1.0mg / ml
Formulation:	Supplied at 1.0mg / mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage:	Store at -20˚C

Target

Function:	Regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D2/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex (By similarity).
Involvement in Disease:	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 3: A syndrome characterized by megalencephaly, ventriculomegaly that may lead to hydrocephalus, and polymicrogyria; polydactyly may also be seen. There is considerable phenotypic similarity between this disorder and the megalencephaly-capillary malformation syndrome.
Sequence Similarities:	Belongs to the cyclin family. Cyclin D subfamily.
Post-Translational Modification:	Polyubiquitinated by the SCF(FBXL2) complex, leading to proteasomal degradation.
Cellular Location:	Nucleus. Cytoplasm. Membrane. Cyclin D-CDK4 complexes accumulate at the nuclear membrane and are then translocated into the nucleus through interaction with KIP/CIP family members.
Database Links:	Entrez Gene: 894 Human Entrez Gene: 12444 Mouse Entrez Gene: 64033 Rat Omim: 123833 Human SwissProt: P30279 Human SwissProt: P30280 Mouse SwissProt: Q04827 Rat Unigene: 376071 Human Unigene: 333406 Mouse Unigene: 96083 Rat
Synonyms:	CCND 2 Antibody ccnd2 Antibody CCND2_HUMAN Antibody Cyclin D2 Antibody CyclinD2 Antibody G1/S specific cyclin D2 Antibody G1/S-specific cyclin-D2 Antibody KIAK0002 Antibody MGC102758 Antibody MPPH3 Antibody
Information:	Target information shown above is from the UniProt Consortium.