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Anti-CCNC Antibody

品牌：Antibodies

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规格：50µl

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Anti-CCNC Antibody

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Name:	Anti-CCNC Antibody See all CCNC primary antibodies
Description:	Rabbit polyclonal antibody to CCNC
Specificity:	CCNC polyclonal antibody detects endogenous levels of CCNC protein.
Applications:	WB, IHC
Reactivity:	Human, Mouse, Rat
Immunogen:	Recombinant full length Human CCNC.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Molecular Weight:	~ 33 kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form:	1mg/ml in PBS?with?0.1%?Sodium?Azide,?50%?Glycerol.

Function:	Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Binds to and activates cyclin-dependent kinase CDK8 that phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex.
Tissue Specificity:	Highest levels in pancreas. High levels in heart, liver, skeletal muscle and kidney. Low levels in brain.
Sequence Similarities:	Belongs to the cyclin family. Cyclin C subfamily.
Cellular Location:	Nucleus.
Database Links:	Entrez Gene: 892?Human Entrez Gene: 51813?Mouse Entrez Gene: 114839?Rat Omim: 123838?Human SwissProt: P24863?Human SwissProt: Q62447?Mouse SwissProt: P39947?Rat Unigene: 430646?Human Unigene: 633351?Human Unigene: 278584?Mouse Unigene: 106758?Rat
Synonyms:	ccnc Antibody CCNC_HUMAN Antibody CycC Antibody Cyclin C Antibody Cyclin-C Antibody hSRB11 Antibody OTTHUMP00000016897 Antibody SRB11 homolog Antibody
Information:	Target information shown above is from the UniProt Consortium.