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Anti-CCDC98 Antibody

品牌：Antibodies

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规格：100µl

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Anti-CCDC98 Antibody

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Overview

Name:	Anti-CCDC98 Antibody See all CCDC98 primary antibodies
Description:	Rabbit polyclonal antibody to CCDC98
Applications:	E, WB, IHC
Reactivity:	Human, Mouse
Immunogen:	Raised against a 15 amino acid peptide from near the amino terminus of human CCDC98.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	Affinity chromatography purified via peptide column
Formulation:	Supplied in PBS containing 0.02% sodium azide.
Storage:	Can be stored at -20?C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target

Function:	Involved in DNA damage response and double-strand break (DSB) repair. Component of the BRCA1-A complex, acting as a central scaffold protein that assembles the various components of the complex and mediates the recruitment of BRCA1. The BRCA1-A complex specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesion sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at DSBs. This complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX.
Sequence Similarities:	Belongs to the FAM175 family. Abraxas subfamily.
Post-Translational Modification:	Phosphorylation of Ser-404 of the pSXXF motif by ATM or ATR constitutes a specific recognition motif for the BRCT domain of BRCA1.
Cellular Location:	Nucleus. Localizes at sites of DNA damage at double-strand breaks (DSBs).
Database Links:	Entrez Gene: 84142?Human Entrez Gene: 70681?Mouse Omim: 611143?Human SwissProt: Q6UWZ7?Human SwissProt: Q8BPZ8?Mouse Unigene: 334772?Human Unigene: 221269?Mouse
Synonyms:	3830405G04Rik Antibody 5630400M01Rik Antibody ABRA1 Antibody ABRAXAS Antibody Abraxas protein Antibody AI506069 Antibody AL024423 Antibody AV118690 Antibody BRCA1-A complex subunit Abraxas Antibody CCDC98 Antibody coiled coil domain containing 98 Antibody Coiled-coil domain-containing protein 98 Antibody F175A_HUMAN Antibody FAM175A Antibody Family with sequence similarity 175 member A Antibody FLJ11520 Antibody FLJ12642 Antibody FLJ13614 Antibody Protein FAM175A Antibody
Information:	Target information shown above is from the UniProt Consortium.