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Anti-CCDC88A Antibody

品牌：Antibodies

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规格：100µl

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Anti-CCDC88A Antibody

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Overview

Name:	Anti-CCDC88A Antibody See all CCDC88A primary antibodies
Description:	Rabbit polyclonal antibody to CCDC88A
Specificity:	The antibody detects endogenous levels of total CCDC88A protein.
Applications:	IHC
Reactivity:	Human, Mouse
Immunogen:	Synthetic peptide corresponding to a region derived from internal residues of human coiled-coil domain containing 88A
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	Antigen affinity purification.
Concentration:	2.7mg / ml
Formulation:	Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
Storage:	Store at -20?C

Target

Function:	Plays a role as a key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during ***** neurogenesis, including correct neuron positioning, dendritic development and synapse formation (By similarity). Enhances phosphoinositide 3-kinase (PI3K)-dependent phosphorylation and kinase activity of AKT1/PKB, but does not possess kinase activity itself (By similarity). Phosphorylation of AKT1/PKB thereby induces the phosphorylation of downstream effectors GSK3 and FOXO1/FKHR, and regulates DNA replication and cell proliferation (By similarity). Essential for the integrity of the actin cytoskeleton and for cell migration (PubMed:16139227). Required for formation of actin stress fibers and lamellipodia (PubMed:15882442). May be involved in membrane sorting in the early endosome (PubMed:15882442). Plays a role in ciliogenesis and cilium morphology and positioning and this may partly be through regulation of the localization of scaffolding protein CROCC/Rootletin (PubMed:27623382).
Tissue Specificity:	Expressed ubiquitously.
Involvement in Disease:	PEHO syndrome: An autosomal recessive syndrome characterized by progressive encephalopathy, lack of psychomotor development, severe mental retardation, early onset epileptic seizures, optic nerve/cerebellar atrophy, pedal edema, and early death.
Sequence Similarities:	Belongs to the CCDC88 family.
Post-Translational Modification:	Phosphorylation is induced by epidermal growth factor (EGF) in a phosphoinositide 3-kinase (PI3K)-dependent manner. Phosphorylation by AKT1/PKB is necessary for the delocalization from the cell membrane and for cell migration.
Cellular Location:	Membrane. Cell membrane. Cytoplasm > Cytosol. Cytoplasmic vesicle. Cell projection > Lamellipodium. Cytoplasm > Cytoskeleton > Cilium basal body. Cytoplasm > Cytoskeleton > Microtubule organizing center > Centrosome > Centriole. Localizes to the cell membrane through interaction with phosphoinositides.
Database Links:	Entrez Gene: 55704?Human Entrez Gene: 108686?Mouse Omim: 609736?Human SwissProt: Q3V6T2?Human SwissProt: Q5SNZ0?Mouse Unigene: 292925?Human Unigene: 338284?Mouse Unigene: 441367?Mouse
Synonyms:	AKT iphosphorylation enhancer Antibody Akt phosphorylation enhancer Antibody APE Antibody Ccdc88a Antibody Coiled coil domain containing 88A Antibody Coiled coil domain containing protein 88A Antibody Coiled-coil domain-containing protein 88A Antibody FLJ10392 Antibody G alpha interacting vesicle associated protein Antibody G alpha-interacting vesicle-associated protein Antibody Galpha interacting vesicle associated protein Antibody Girders of actin filament Antibody Girdin Antibody GIV Antibody GRDN Antibody GRDN_HUMAN Antibody HkRP1 Antibody Hook related protein 1 Antibody Hook-related protein 1 Antibody KIAA1212 Antibody
Information:	Target information shown above is from the UniProt Consortium.