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Anti-CBX3 Antibody

品牌：Antibodies

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规格：100µg

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应用：

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Anti-CBX3 Antibody

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Overview

Name:	Anti-CBX3 Antibody See all HP1 gamma primary antibodies
Description:	Goat polyclonal antibody to CBX3.
Applications:	ELISA, WB, IHC
Reactivity:	Human, Mouse
Immunogen:	Synthetic peptide corresponding to Human CBX3 (internal region).
Sequence:	C-EAFLNSQKAGKEKD
Host:	Goat
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Unconjugated
Purification:	Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration:	100 μg at 0.5 mg/ml.
Product Form:	Liquid
Formulation:	Supplied in Tris Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 0.5% BSA.
Storage:	Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Target

Function:	Component of heterochromatin. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. Probably involved in the repression of many genes located in euchromatin, such as E2F1, MYC and CDC25A. Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. Contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation, mediates the recruitment of the methyltransferases SUV39H1 and/or SUV39H2 by the PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1 (PubMed:24413057). Mediates the recruitement of NIPBL to sites of DNA damage at double-strand breaks (DSBs) (By similarity).
Post-Translational Modification:	Phosphorylated by PIM1. Phosphorylated during interphase and possibly hyper-phosphorylated during mitosis (By similarity).
Cellular Location:	Nucleus. May be associated with microtubules and mitotic poles during mitosis (Potential). Associates with euchromatin and is largely excluded from constitutive heterochromatin.
Database Links:	Entrez Gene: 11335?Human Entrez Gene: 12417?Mouse Omim: 604477?Human SwissProt: Q13185?Human SwissProt: P23198?Mouse Unigene: 381189?Human Unigene: 280968?Mouse Unigene: 458234?Mouse Unigene: 485141?Mouse
Synonyms:	CBX 3 Antibody CBX3 Antibody CBX3_HUMAN Antibody Chromobox homolog 3 Antibody Chromobox homolog 3 (HP1 gamma homolog, Drosophila) Antibody Chromobox protein homolog 3 Antibody GAMMA Antibody HECH Antibody Heterochromatin like protein 1 Antibody Heterochromatin protein 1 homolog gamma Antibody Heterochromatin protein HP1 gamma Antibody HP1 gamma Antibody HP1 gamma homolog Antibody HP1Hs gamma Antibody Modifier 2 protein Antibody
Information:	Target information shown above is from the UniProt Consortium.