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Anti-CBLB Antibody

品牌：Antibodies

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规格：50µl

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Anti-CBLB Antibody

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Overview

Name:	Anti-CBLB Antibody See all CBLB primary antibodies
Description:	Rabbit polyclonal antibody to CBLB.
Applications:	WB, IHC
Dilutions:	WB: 1:500 - 1:2000, IHC: 1:50 - 1:200.
Reactivity:	Human, Mouse, Rat
Immunogen:	Recombinant protein of human CBLB.
Protein Length:	982
Host:	Rabbit
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Unconjugated
Purification:	Affinity purification.
Product Form:	Liquid
Formulation:	Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage:	Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Target

Function:	E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. Negatively regulates TCR (T-cell receptor), BCR (B-cell receptor) and FCER1 (high affinity immunoglobulin epsilon receptor) signal transduction pathways. In naive T-cells, inhibits VAV1 activation upon TCR engagement and imposes a requirement for CD28 costimulation for proliferation and IL-2 production. Also acts by promoting PIK3R1/p85 ubiquitination, which impairs its recruitment to the TCR and subsequent activation. In activated T-cells, inhibits PLCG1 activation and calcium mobilization upon restimulation and promotes anergy. In B-cells, acts by ubiquitinating SYK and promoting its proteasomal degradation. Slightly promotes SRC ubiquitination. May be involved in EGFR ubiquitination and internalization. May be functionally coupled with the E2 ubiquitin-protein ligase UB2D3.
Tissue Specificity:	Expressed in placenta, heart, lung, kidney, spleen, ovary and testis, as well as fetal brain and liver and hematopoietic cell lines, but not in ***** brain, liver, pancreas, salivary gland, or skeletal muscle. Present in lymphocytes (at protein level).
Post-Translational Modification:	Phosphorylated on tyrosine and serine residues upon TCR or BCR activation, and upon various types of cell stimulation.
Cellular Location:	Cytoplasm. Upon EGF stimulation, associates with endocytic vesicles.
Database Links:	Entrez Gene: 868?Human Entrez Gene: 208650?Mouse Entrez Gene: 171136?Rat Omim: 604491?Human SwissProt: Q13191?Human SwissProt: Q3TTA7?Mouse SwissProt: Q8K4S7?Rat Unigene: 430589?Human Unigene: 328206?Mouse Unigene: 21799?Rat
Synonyms:	AI429560 Antibody AI851073 Antibody Cas Br M (murine) ecotropic retroviral transforming sequence b Antibody Casitas B lineage lymphoma b Antibody Casitas B lineage lymphoma proto oncogene b Antibody Casitas B-lineage lymphoma proto-oncogene b Antibody Cbl b Antibody CBLB Antibody CBLB_HUMAN Antibody DKFZp686J10223 Antibody DKFZp779A0729 Antibody DKFZp779F1443 Antibody E3 ubiquitin protein ligase CBL B Antibody E3 ubiquitin-protein ligase CBL-B Antibody EC 6.3.2.- Antibody FLJ36865 Antibody FLJ41152 Antibody Nbla00127 Antibody RING finger protein 56 Antibody RNF56 Antibody SH3 binding protein CBL B Antibody SH3-binding protein CBL-B Antibody Signal transduction protein CBL B Antibody Signal transduction protein CBL-B Antibody
Information:	Target information shown above is from the UniProt Consortium.