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Anti-CBFA2T2 Antibody

品牌：Antibodies

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规格：50µl

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Anti-CBFA2T2 Antibody

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Overview

Name:	Anti-CBFA2T2 Antibody See all CBFA2T2 primary antibodies
Description:	Rabbit polyclonal antibody to CBFA2T2.
Applications:	WB, IHC, IF
Dilutions:	WB: 1:500 - 1:2000, IHC: 1:50 - 1:200, IF: 1:50 - 1:100.
Reactivity:	Human, Mouse, Rat
Immunogen:	Recombinant protein of human CBFA2T2.
Protein Length:	604
Host:	Rabbit
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Unconjugated
Purification:	Affinity purification.
Product Form:	Liquid
Formulation:	Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage:	Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Target

Function:	Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes (PubMed:12559562, PubMed:15203199). Via association with PRDM14 is involved in regulation of embryonic stem cell (ESC) pluripotency (PubMed:27281218). Involved in primordial germ cell (PCG) formation. Stabilizes PRDM14 and OCT4 on chromatin in a homooligomerization-dependent manner (By similarity). Can repress the expression of MMP7 in a ZBTB33-dependent manner (PubMed:23251453). May function as a complex with the chimeric protein RUNX1/AML1-CBFA2T1/MTG8 (AML1-MTG8/ETO fusion protein) which is produced in acute myeloid leukemia with the chromosomal translocation t(8;21). May thus be involved in the repression of AML1-dependent transcription and the induction of G-CSF/CSF3-dependent cell growth. May be a tumor suppressor gene candidate involved in myeloid tumors with the deletion of the 20q11 region. Through heteromerization with CBFA2T3/MTG16 may be involved in regulation of the proliferation and the differentiation of erythroid progenitors by repressing the expression of TAL1 target genes (By similarity). Required for the maintenance of the secretory cell lineage in the small intestine. Can inhibit Notch signaling probably by association with RBPJ and may be involved in GFI1-mediated Paneth cell differentiation (By similarity).
Tissue Specificity:	Ubiquitously expressed in fetal and *** tissues. Highly expressed in *** brain, heart, lung, kidney, lymph node, appendix, thymus, testis, uterus, small intestine, prostate and thymus.
Sequence Similarities:	Belongs to the CBFA2T family.
Cellular Location:	Nucleus.
Database Links:	Entrez Gene: 9139?Human Entrez Gene: 12396?Mouse Entrez Gene: 296293?Rat Omim: 601308?Human Omim: 603672?Human SwissProt: O43439?Human SwissProt: O70374?Mouse Unigene: 153934?Human Unigene: 29914?Mouse Unigene: 58348?Rat
Synonyms:	AML1 MTG8 Antibody cbfa2t2 Antibody Core binding factor runt domain alpha subunit 2 translocated to 2 Antibody core-binding factor, runt domain, alpha subunit 2 Antibody DKFZp313F2116 Antibody EHT Antibody ETO homolog on chromosome 20 Antibody ETO homologous on chromosome 20 Antibody MTG 8 like protein Antibody MTG 8 related protein 1 Antibody MTG8 like protein Antibody MTG8 related protein 1 Antibody MTG8-like protein Antibody MTG8-related protein 1 Antibody MTG8R_HUMAN Antibody MTGR 1 Antibody MTGR1 Antibody Myeloid translocation gene related protein 1 Antibody Myeloid translocation related protein 1 Antibody Myeloid translocation-related protein 1 Antibody p85 Antibody Protein CBFA2T2 Antibody ZMYND 3 Antibody ZMYND3 Antibody
Information:	Target information shown above is from the UniProt Consortium.