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Anti-cathepsin D Antibody

品牌：Antibodies

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规格：100µl

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Anti-cathepsin D Antibody

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Overview

Name:	Anti-cathepsin D Antibody See all cathepsin D primary antibodies
Description:	Rabbit polyclonal antibody to cathepsin D
Applications:	WB, IHC
Reactivity:	Human
Immunogen:	Recombinant protein fragment contain a sequence corresponding to a region within amino acids 72 and 262 of Human CTSD
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	Purified by antigen-affinity chromatography.
Formulation:	Supplied in 0.1M Tris-buffered saline with 10% Glycerol (pH7.0). 0.01% Thimerosal was added as a preservative.
Storage:	Store at -20?C for long term preservation (recommended). Store at 4?C for short term use.

Target

Function:	Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation (PubMed:27333034). Involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease.
Tissue Specificity:	Expressed in the aorta extrcellular space (at protein level) (PubMed:20551380). Expressed in liver (at protein level) (PubMed:1426530).
Involvement in Disease:	Ceroid lipofuscinosis, neuronal, 10: A form of neuronal ceroid lipofuscinosis with onset at birth or early childhood. Neuronal ceroid lipofuscinoses are progressive neurodegenerative, lysosomal storage diseases characterized by intracellular accumulation of autofluorescent liposomal material, and clinically by seizures, dementia, visual loss, and/or cerebral atrophy.
Sequence Similarities:	Belongs to the peptidase A1 family.
Post-Translational Modification:	N- and O-glycosylated.
Cellular Location:	Lysosome. Melanosome. Secreted > Extracellular space. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. In aortic samples, detected as an extracellular protein loosely bound to the matrix (PubMed:20551380).
Database Links:	Entrez Gene: 1509?Human Omim: 116840?Human SwissProt: P07339?Human Unigene: 546248?Human Unigene: 654447?Human
Synonyms:	CatD Antibody CATD_HUMAN Antibody Cathepsin D Antibody Cathepsin D heavy chain Antibody CD Antibody Ceroid lipofuscinosis neuronal 10 Antibody CLN10 Antibody CPSD Antibody CTSD Antibody Epididymis secretory sperm binding protein Li 130P Antibody HEL S 130P Antibody Lysosomal aspartyl peptidase Antibody Lysosomal aspartyl protease Antibody MGC2311 Antibody
Information:	Target information shown above is from the UniProt Consortium.