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Anti-Caspase-1 Antibody

品牌：Antibodies

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规格：100µl

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Anti-Caspase-1 Antibody

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Name:	Anti-Caspase-1 Antibody See all Caspase-1 primary antibodies
Description:	Rabbit polyclonal antibody to Caspase-1
Specificity:	Depending on cell lines or tissues used, other cleavage products may be observed.
Applications:	E, WB, IHC
Reactivity:	Human
Immunogen:	Raised against a 16 amino acid peptide from near the carboxy terminus of human Caspase-1.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	Affinity chromatography purified via peptide column
Formulation:	Supplied in PBS containing 0.02% sodium azide.
Storage:	Can be stored at -20?C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Function:	Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis.
Tissue Specificity:	Expressed in larger amounts in spleen and lung. Detected in liver, heart, small intestine, colon, thymus, prostate, skeletal muscle, peripheral blood leukocytes, kidney and testis. No expression in the brain.
Sequence Similarities:	Belongs to the peptidase C14A family.
Post-Translational Modification:	The two subunits are derived from the precursor sequence by an autocatalytic mechanism.
Cellular Location:	Cytoplasm.
Database Links:	Entrez Gene: 834?Human Omim: 147678?Human SwissProt: P29466?Human Unigene: 2490?Human
Synonyms:	CASP-1 Antibody CASP1 Antibody CASP1_HUMAN Antibody Caspase 1 Antibody Caspase-1 Antibody Caspase-1 subunit p10 Antibody ICE Antibody IL-1 beta-converting enzyme Antibody IL-1BC Antibody IL1 beta converting enzyme Antibody IL1B convertase Antibody Interleukin 1 beta convertase Antibody Interleukin 1B converting enzyme Antibody Interleukin-1 beta convertase Antibody Interleukin-1 beta-converting enzyme Antibody p45 Antibody
Information:	Target information shown above is from the UniProt Consortium.