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Anti-CAPN1 Antibody

品牌：Antibodies

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规格：50µl

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Anti-CAPN1 Antibody

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Overview

Name:	Anti-CAPN1 Antibody See all CAPN1 primary antibodies
Description:	Rabbit polyclonal antibody to CAPN1.
Applications:	WB, IHC
Dilutions:	WB: 1:500 - 1:2000, IHC: 1:50 - 1:200.
Reactivity:	Human, Mouse, Rat
Immunogen:	Recombinant protein of human CAPN1.
Protein Length:	714
Host:	Rabbit
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Unconjugated
Purification:	Affinity purification.
Product Form:	Liquid
Formulation:	Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage:	Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Target

Function:	Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction.
Tissue Specificity:	Ubiquitous.
Involvement in Disease:	Spastic paraplegia 76, autosomal recessive: A form of spastic paraplegia, a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. Rate of progression and the severity of symptoms are quite variable. Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking. In some forms of the disorder, bladder symptoms (such as incontinence) may appear, or the weakness and stiffness may spread to other parts of the body.
Sequence Similarities:	Belongs to the peptidase C2 family.
Post-Translational Modification:	Undergoes calcium-induced successive autoproteolytic cleavages that generate a membrane-bound 78 kDa active form and an intracellular 75 kDa active form. Calpastatin reduces with high efficiency the transition from 78 kDa to 75 kDa calpain forms.
Cellular Location:	Cytoplasm. Cell membrane. Translocates to the plasma membrane upon Ca(2+) binding. In granular keratinocytes and in lower corneocytes, colocalizes with FLG and FLG2 (PubMed:21531719).
Database Links:	Entrez Gene: 823?Human Entrez Gene: 12333?Mouse Entrez Gene: 29153?Rat Omim: 114220?Human SwissProt: P07384?Human SwissProt: O35350?Mouse SwissProt: P97571?Rat Unigene: 502842?Human Unigene: 6221?Mouse Unigene: 6037?Rat
Synonyms:	Ca2 activated neutral protease Antibody Calcium activated neutral proteinase Antibody Calcium activated neutral proteinase small subunit Antibody Calcium dependent protease small subunit Antibody Calcium dependent protease small subunit 1 Antibody Calcium-activated neutral proteinase 1 Antibody Calpain 1 Antibody Calpain 1 large subunit Antibody Calpain 1, (mu/I) large subunit Antibody Calpain mu type Antibody Calpain mu-type Antibody Calpain regulatory subunit Antibody Calpain small subunit 1 Antibody Calpain, large polypeptide L1 Antibody Calpain-1 catalytic subunit Antibody Calpain-1 large subunit Antibody CAN1_HUMAN Antibody CANP Antibody CANP 1 Antibody CANP small subunit Antibody CANP1 Antibody CANPL 1 Antibody CANPL1 Antibody CAPN 1 Antibody CAPN1 Antibody Cell proliferation inducing protein 30 Antibody Cell proliferation-inducing gene 30 protein Antibody Micromolar Calpain Antibody Micromolar-calpain Antibody Mu Calpain Antibody muCANP Antibody muCL Antibody
Information:	Target information shown above is from the UniProt Consortium.