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Anti-CANX Antibody

品牌：Antibodies

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规格：100µl

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Anti-CANX Antibody

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Overview

Name:	Anti-CANX Antibody See all CANX primary antibodies
Description:	Rabbit polyclonal antibody to CANX
Specificity:	The antibody detects endogenous levels of total CANX protein.
Applications:	WB, IHC
Reactivity:	Human, Mouse
Immunogen:	Fusion protein corresponding to a region derived from internal residues of human calnexin
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	Antigen affinity purification.
Concentration:	1.9mg / ml
Formulation:	Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
Storage:	Store at -20?C

Target

Function:	Calcium-binding protein that interacts with newly synthesized glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor-mediated endocytosis at the synapse.
Sequence Similarities:	Belongs to the calreticulin family.
Post-Translational Modification:	Phosphorylated at Ser-564 by MAPK3/ERK1. phosphorylation by MAPK3/ERK1 increases its association with ribosomes (By similarity).
Cellular Location:	Endoplasmic reticulum membrane. Endoplasmic reticulum. Melanosome. Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:12643545, PubMed:17081065). The palmitoylated form preferentially localizes to the perinuclear rough ER (PubMed:22314232).
Database Links:	Entrez Gene: 821?Human Entrez Gene: 12330?Mouse Omim: 114217?Human SwissProt: P27824?Human SwissProt: P35564?Mouse Unigene: 567968?Human Unigene: 248827?Mouse
Synonyms:	Calnexin Antibody CALX_HUMAN Antibody CANX Antibody CNX Antibody FLJ26570 Antibody Histocompatibility complex class I antigen binding protein p88 Antibody IP90 Antibody Major histocompatibility complex class I antigen-binding protein p88 Antibody p90 Antibody
Information:	Target information shown above is from the UniProt Consortium.