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Anti-CAMKK2 Antibody

品牌：Antibodies

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规格：50µl

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Anti-CAMKK2 Antibody

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Overview

Name:	Anti-CAMKK2 Antibody See all CAMKK2 primary antibodies
Description:	Rabbit polyclonal antibody to CAMKK2
Specificity:	The antibody detects endogenous levels of total CAMKK2 protein.
Applications:	WB, IHC
Reactivity:	Human
Immunogen:	Synthesized peptide derived from internal of human CAMKK2.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:	1.0mg / ml
Formulation:	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage:	Store at -20?C

Target

Function:	Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Isoform 1, isoform 2 and isoform 3 phosphorylate CAMK1 and CAMK4. Isoform 3 phosphorylates CAMK1D. Isoform 4, isoform 5 and isoform 6 lacking part of the calmodulin-binding domain are inactive. Efficiently phosphorylates 5'-AMP-activated protein kinase (AMPK) trimer, including that consisting of PRKAA1, PRKAB1 and PRKAG1. This phosphorylation is stimulated in response to Ca(2+) signals (By similarity). Seems to be involved in hippocampal activation of CREB1 (By similarity). May play a role in neurite growth. Isoform 3 may promote neurite elongation, while isoform 1 may promoter neurite branching.
Tissue Specificity:	Ubiquitously expressed with higher levels in the brain. Intermediate levels are detected in spleen, prostate, thyroid and leukocytes. The lowest level is in lung.
Sequence Similarities:	Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
Post-Translational Modification:	Autophosphorylated and phosphorylated by PKA. Each isoform may show a different pattern of phosphorylation.
Cellular Location:	Nucleus. Cytoplasm. Cell projection. Predominantly nuclear in unstimulated cells (By similarity). Found in the cytoplasm and neurites after forskolin induction.
Database Links:	Entrez Gene: 10645?Human Omim: 615002?Human SwissProt: Q96RR4?Human Unigene: 297343?Human
Synonyms:	Calcium/calmodulin dependent protein kinase beta Antibody Calcium/calmodulin dependent protein kinase kinase 2 Antibody Calcium/calmodulin dependent protein kinase kinase 2 beta Antibody Calcium/calmodulin dependent protein kinase kinase beta Antibody Calcium/calmodulin-dependent protein kinase kinase 2 Antibody Calcium/calmodulin-dependent protein kinase kinase beta Antibody CaM kinase kinase beta Antibody CaM KK beta Antibody CaM-kinase kinase 2 Antibody CaM-kinase kinase beta Antibody CaM-KK 2 Antibody CaM-KK beta Antibody CAMKK Antibody CaMKK 2 Antibody CaMKK beta Antibody CAMKK beta protein Antibody CAMKK2 Antibody CAMKKB Antibody KKCC2_HUMAN Antibody
Information:	Target information shown above is from the UniProt Consortium.