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Anti-CaMKIV (V192) Antibody

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规格：50µl

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Anti-CaMKIV (V192) Antibody

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Overview

Name:	Anti-CaMKIV (V192) Antibody See all CaMKIV primary antibodies
Description:	Rabbit polyclonal antibody to CaMKIV (V192)
Specificity:	CaMKIV (V192/196) pAb detects endogenous levels of CaMKIV protein.
Applications:	WB, IHC, IF
Reactivity:	Human, Mouse, Rat
Immunogen:	Synthetic peptide, corresponding to amino acids 160-218 of Human CaMKIV.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Molecular Weight:	~ 60 kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form:	1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.

Target

Function:	Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK4 signaling cascade and regulates, mainly by phosphorylation, the activity of several transcription activators, such as CREB1, MEF2D, JUN and RORA, which play pivotal roles in immune response, inflammation, and memory consolidation. In the thymus, regulates the CD4(+)/CD8(+) double positive thymocytes selection threshold during T-cell ontogeny. In CD4 memory T-cells, is required to link T-cell antigen receptor (TCR) signaling to the production of IL2, IFNG and IL4 (through the regulation of CREB and MEF2). Regulates the differentiation and survival phases of osteoclasts and dendritic cells (DCs). Mediates DCs survival by linking TLR4 and the regulation of temporal expression of BCL2. Phosphorylates the transcription activator CREB1 on 'Ser-133' in hippocampal neuron nuclei and contribute to memory consolidation and long term potentiation (LTP) in the hippocampus. Can activate the MAP kinases MAPK1/ERK2, MAPK8/JNK1 and MAPK14/p38 and stimulate transcription through the phosphorylation of ELK1 and ATF2. Can also phosphorylate in vitro CREBBP, PRM2, MEF2A and STMN1/OP18.
Tissue Specificity:	Expressed in brain, thymus, CD4 T-cells, testis and epithelial ovarian cancer tissue.
Sequence Similarities:	Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.
Post-Translational Modification:	Phosphorylated by CaMKK1 and CaMKK2 on Thr-200. Dephosphorylated by protein phosphatase 2A. Autophosphorylated on Ser-12 and Ser-13.
Cellular Location:	Cytoplasm. Nucleus. Localized in hippocampal neuron nuclei. In spermatids, associated with chromatin and nuclear matrix (By similarity).
Database Links:	Entrez Gene: 814?Human Entrez Gene: 12326?Mouse Entrez Gene: 25050?Rat Omim: 114080?Human SwissProt: Q16566?Human SwissProt: P08414?Mouse SwissProt: P13234?Rat Unigene: 591269?Human Unigene: 222329?Mouse Unigene: 11046?Rat
Synonyms:	Brain Ca(2+) calmodulin dependent protein kinase type 4 Antibody Brain Ca(2+) calmodulin dependent protein kinase type IV Antibody Brain Ca++-calmodulin dependent protein kinase type IV Antibody Calcium / calmodulin dependent protein kinase type 4 catalytic chain Antibody Calcium / calmodulin dependent protein kinase type IV catalytic chain Antibody Calcium/calmodulin dependent protein kinase IV Antibody Calcium/calmodulin dependent protein kinase type IV Antibody Calcium/calmodulin-dependent protein kinase type IV Antibody CAM kinase 4 Antibody CAM kinase GR Antibody CAM kinase IV Antibody CAM kinase-GR Antibody CaMK 4 Antibody CAMK GR Antibody CaMK IV Antibody Camk4 Antibody CaMKGR Antibody CAMKIV Antibody IV Antibody KCC4_HUMAN Antibody MGC36771 Antibody
Information:	Target information shown above is from the UniProt Consortium.