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Anti-CaMKII delta Antibody

品牌：Antibodies

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规格：100µl

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Anti-CaMKII delta Antibody

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Overview

Name:	Anti-CaMKII delta Antibody See all CaMKII delta primary antibodies
Description:	Rabbit polyclonal antibody to CaMKII delta
Applications:	WB, IF
Reactivity:	Human
Immunogen:	Recombinant protein fragment contain a sequence corresponding to a region within amino acids 249 and 455 of CaMKII delta
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	Purified by antigen-affinity chromatography.
Formulation:	Supplied in 0.1M Tris-buffered saline with 10% Glycerol (pH7.0). 0.01% Thimerosal was added as a preservative.
Storage:	Store at -20˚C for long term preservation (recommended). Store at 4˚C for short term use.

Target

Function:	Calcium/calmodulin-dependent protein kinase involved in the regulation of Ca(2+) homeostatis and excitation-contraction coupling (ECC) in heart by targeting ion channels, transporters and accessory proteins involved in Ca(2+) influx into the myocyte, Ca(2+) release from the sarcoplasmic reticulum (SR), SR Ca(2+) uptake and Na(+) and K(+) channel transport. Targets also transcription factors and signaling molecules to regulate heart function. In its activated form, is involved in the pathogenesis of dilated cardiomyopathy and heart failure. Contributes to cardiac decompensation and heart failure by regulating SR Ca(2+) release via direct phosphorylation of RYR2 Ca(2+) channel on 'Ser-2808'. In the nucleus, phosphorylates the MEF2 repressor HDAC4, promoting its nuclear export and binding to 14-3-3 protein, and expression of MEF2 and genes involved in the hypertrophic program. Is essential for left ventricular remodeling responses to myocardial infarction. In pathological myocardial remodeling acts downstream of the beta adrenergic receptor signaling cascade to regulate key proteins involved in ECC. Regulates Ca(2+) influx to myocytes by binding and phosphorylating the L-type Ca(2+) channel subunit beta-2 CACNB2. In addition to Ca(2+) channels, can target and regulate the cardiac sarcolemmal Na(+) channel Nav1.5/SCN5A and the K+ channel Kv4.3/KCND3, which contribute to arrhythmogenesis in heart failure. Phosphorylates phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2, contributing to the enhancement of SR Ca(2+) uptake that may be important in frequency-dependent acceleration of relaxation (FDAR) and maintenance of contractile function during acidosis. May participate in the modulation of skeletal muscle function in response to exercise, by regulating SR Ca(2+) transport through phosphorylation of PLN/PLB and triadin, a ryanodine receptor-coupling factor.
Tissue Specificity:	Expressed in cardiac muscle and skeletal muscle. Isoform Delta 3, isoform Delta 2, isoform Delta 8 and isoform Delta 9 are expressed in cardiac muscle. Isoform Delta 11 is expressed in skeletal muscle.
Sequence Similarities:	Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.
Post-Translational Modification:	Autophosphorylation of Thr-287 following activation by Ca(2+)/calmodulin. Phosphorylation of Thr-287 locks the kinase into an activated state.
Cellular Location:	Cell membrane > Sarcolemma. Sarcoplasmic reticulum membrane.
Database Links:	Entrez Gene: 817 Human Omim: 607708 Human SwissProt: Q13557 Human Unigene: 144114 Human
Synonyms:	Calcium / calmodulin dependent protein kinase 2 delta Antibody Calcium / calmodulin dependent protein kinase II delta Antibody calcium/calmodulin-dependent protein kinase (CaM kinase) II delta Antibody calcium/calmodulin-dependent protein kinase type II delta chain Antibody Calcium/calmodulin-dependent protein kinase type II subunit delta Antibody CAM kinase 2 delta Antibody CAM kinase II delta Antibody CaM kinase II delta subunit Antibody CaM kinase II subunit delta Antibody CaM-kinase II delta chain Antibody CAMK 2d Antibody CaMK-II delta subunit Antibody CaMK-II subunit delta Antibody CAMK2D Antibody CAMKD Antibody CAMKI Antibody CaMKII delta Antibody KCC2D_HUMAN Antibody RATCAMKI Antibody
Information:	Target information shown above is from the UniProt Consortium.