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Anti-Calsequestrin-2 Antibody

品牌：Antibodies

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规格：100µl

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Anti-Calsequestrin-2 Antibody

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Overview

Name:	Anti-Calsequestrin-2 Antibody See all Calsequestrin-2 primary antibodies
Description:	Rabbit polyclonal antibody to Calsequestrin-2
Applications:	WB, IHC
Reactivity:	Human
Immunogen:	Recombinant protein fragment contain a sequence corresponding to a region within amino acids 124 and 398 of Human CASQ2
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	Purified by antigen-affinity chromatography.
Formulation:	Supplied in 0.1M Tris-buffered saline with 10% Glycerol (pH7.0). 0.01% Thimerosal was added as a preservative.
Storage:	Store at -20?C for long term preservation (recommended). Store at 4?C for short term use.

Target

Function:	Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle. Calcium ions are bound by clusters of acidic residues at the protein surface, especially at the interface between subunits. Can bind around 60 Ca(2+) ions. Regulates the release of lumenal Ca(2+) via the calcium release channel RYR2; this plays an important role in triggering muscle contraction. Plays a role in excitation-contraction coupling in the heart and in regulating the rate of heart beats.
Involvement in Disease:	Ventricular tachycardia, catecholaminergic polymorphic, 2: An arrhythmogenic disorder characterized by stress-induced, bidirectional ventricular tachycardia that may degenerate into cardiac arrest and cause sudden death. Patients present with recurrent syncope, seizures, or sudden death after physical activity or emotional stress. CPVT2 inheritance is autosomal recessive.
Sequence Similarities:	Belongs to the calsequestrin family.
Post-Translational Modification:	Phosphorylation in the C-terminus, probably by CK2, moderately increases calcium buffering capacity.
Cellular Location:	Sarcoplasmic reticulum lumen. This isoform of calsequestrin occurs in the sarcoplasmic reticulum's terminal cisternae luminal spaces of cardiac and slow skeletal muscle cells.
Database Links:	Entrez Gene: 845?Human Omim: 114251?Human SwissProt: O14958?Human Unigene: 57975?Human
Synonyms:	AA033488 Antibody AW146219 Antibody Calsequestrin Antibody Calsequestrin 2 Antibody Calsequestrin 2 (cardiac muscle) Antibody Calsequestrin 2 fast twitch cardiac muscle Antibody Calsequestrin cardiac muscle isoform Antibody Calsequestrin fast twitch cardiac muscle Antibody Calsequestrin-2 Antibody Calsequestrin2 Antibody cardCSQ Antibody Cardiac calsequestrin 2 Antibody cardiac muscle isoform Antibody CASQ 2 Antibody CASQ2 Antibody CASQ2_HUMAN Antibody cCSQ Antibody ESTM52 Antibody FLJ26321 Antibody FLJ93514 Antibody PDIB2 Antibody
Information:	Target information shown above is from the UniProt Consortium.