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Anti-Calreticulin Antibody

品牌：Antibodies

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规格：50µl

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Anti-Calreticulin Antibody

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Overview

Name:	Anti-Calreticulin Antibody See all Calreticulin primary antibodies
Description:	Mouse monoclonal (6C6) antibody to Calreticulin.
Applications:	WB, ICC/IF, IHC
Dilutions:	WB: 1:1,000-5,000. ICC/IF or IHC: 1:1,000-5,000.
Reactivity:	Human, Rat, Mouse
Immunogen:	Synthetic peptides VESGSLEDDWDFLPPKKI corresponding to amino acids 191-208 of human calreticulin, including the LC3 interacting region or LIR.
Host:	Mouse
Clonality:	Monoclonal
Clone:	6C6
Isotype:	IgG1
Conjugate:	Unconjugated
Purification:	Immunogen affinity purified.
Concentration:	1 mg/ml
Product Form:	Liquid
Formulation:	Supplied in Phosphate Buffered Saline with 50% Glycerol and 5mM Sodium Azide.
Storage:	Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Target

Function:	Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER. Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export. Involved in maternal gene expression regulation. May participate in oocyte maturation via the regulation of calcium homeostasis.
Tissue Specificity:	Predentin and odontoblast.
Sequence Similarities:	Belongs to the calreticulin family.
Cellular Location:	Endoplasmic reticulum lumen. Sarcoplasmic reticulum lumen.
Database Links:	Entrez Gene: 811?Human Entrez Gene: 12317?Mouse Entrez Gene: 64202?Rat Omim: 109091?Human SwissProt: P27797?Human SwissProt: P14211?Mouse SwissProt: P18418?Rat Unigene: 515162?Human Unigene: 1971?Mouse Unigene: 467043?Mouse Unigene: 974?Rat
Synonyms:	Autoantigen RO Antibody CALR Antibody CALR protein Antibody Calregulin Antibody Calreticulin Antibody CALR_HUMAN Antibody cC1qR Antibody CRP55 Antibody CRT Antibody CRTC Antibody Endoplasmic reticulum resident protein 60 Antibody Epididymis secretory sperm binding protein Li 99n Antibody ERp60 Antibody FLJ26680 Antibody grp60 Antibody HACBP Antibody HEL S 99n Antibody RO Antibody Sicca syndrome antigen A Antibody Sicca syndrome antigen A (autoantigen Ro; calreticulin) Antibody SSA Antibody
Information:	Target information shown above is from the UniProt Consortium.