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Anti-CAD Antibody

品牌：Antibodies

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规格：100µl

货期：

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Anti-CAD Antibody

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Overview

Name:	Anti-CAD Antibody See all CAD primary antibodies
Description:	Rabbit polyclonal antibody to CAD
Applications:	E, WB, IHC
Reactivity:	Mouse, Rat
Immunogen:	Raised against a peptide corresponding to 17 amino acids near the center of murine CAD.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	Affinity chromatography purified via peptide column
Formulation:	Supplied in PBS containing 0.02% sodium azide.
Storage:	Can be stored at -20?C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target

Function:	This protein is a "fusion" protein encoding four enzymatic activities of the pyrimidine pathway (GATase, CPSase, ATCase and DHOase).
Sequence Similarities:	In the central section; belongs to the metallo-dependent hydrolases superfamily. DHOase family. CAD subfamily.
Post-Translational Modification:	Activated by MAP kinase (Erk1/2) phosphorylation just prior to the S phase of the cell cycle, when the demand for pyrimidine nucleotides is greatest, and down-regulated as the cells emerge from S phase by protein kinase A (PKA) phosphorylation. Phosphorylation at Ser-1859 by RPS6KB1 downstream of MTOR promotes oligomerization and stimulates dihydroorotase activity. Phosphorylation at Ser-1406 reduces sensitivy to feedback inhibition by UTP (By similarity).
Cellular Location:	Cytoplasm. Nucleus. Cytosolic and unphosphorylated in resting cells, translocates to the nucleus in response to EGF stimulation, nuclear import promotes optimal cell growth.
Database Links:	Entrez Gene: 69719?Mouse Entrez Gene: 24240?Rat SwissProt: B2RQC6?Mouse Unigene: 19416?Rat
Synonyms:	Aspartate carbamoyltransferase Antibody Aspartate transcarbamylase Antibody CAD Antibody CAD protein Antibody CAD trifunctional protein Antibody Carbamoyl phosphate synthetase 2 Antibody Carbamoyl-phosphate synthetase 2 aspartate transcarbamylase and dihydroorotase Antibody CPSase ATCase DHOase Antibody Dihydroorotase Antibody Glutamine dependent carbamoyl phosphate synthase Antibody Multifunctional protein CAD Antibody
Information:	Target information shown above is from the UniProt Consortium.