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Anti-CACNB2 Antibody

品牌：Antibodies

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规格：100µl

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Anti-CACNB2 Antibody

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Overview

Name:	Anti-CACNB2 Antibody See all CACNB2 primary antibodies
Description:	Rabbit polyclonal antibody to CACNB2
Specificity:	The antibody detects endogenous levels of total CACNB2 protein.
Applications:	IHC
Reactivity:	Human, Mouse, Rat
Immunogen:	Synthetic peptide corresponding to a region derived from internal residues of human calcium channel, voltage-dependent, beta 2 subunit
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	Antigen affinity purification.
Concentration:	1.7mg / ml
Formulation:	Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
Storage:	Store at -20?C

Target

Function:	The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting.
Tissue Specificity:	Expressed in all tissues.
Involvement in Disease:	Brugada syndrome 4: A heart disease characterized by the association of Brugada syndrome with shortened QT intervals. Brugada syndrome is a tachyarrhythmia characterized by right bundle branch block and ST segment elevation on an electrocardiogram (ECG). It can cause the ventricles to beat so fast that the blood is prevented from circulating efficiently in the body. When this situation occurs, the individual will faint and may die in a few minutes if the heart is not reset.
Sequence Similarities:	Belongs to the calcium channel beta subunit family.
Post-Translational Modification:	Regulated through phosphorylation at Thr-554 by CaMK2D.
Cellular Location:	Cell membrane > Sarcolemma.
Database Links:	Entrez Gene: 783?Human Entrez Gene: 12296?Mouse Entrez Gene: 116600?Rat Omim: 600003?Human SwissProt: Q08289?Human SwissProt: Q8CC27?Mouse SwissProt: Q8VGC3?Rat Unigene: 59093?Human Unigene: 313930?Mouse Unigene: 10739?Rat
Synonyms:	AW060387 Antibody Ca(V) beta 2 Antibody CAB2 Antibody CACB2_HUMAN Antibody CACNB2 Antibody CACNLB2 Antibody Calcium channel voltage dependent subunit beta 2 Antibody Calcium channel voltage-dependent subunit beta 2 Antibody Calcium channel, voltage dependent, beta 2 subunit Antibody CAVB2 Antibody Cavbeta2 Antibody Cchb2 Antibody FLJ23743 Antibody Lambert Eaton Myasthenic syndrome antigen Antibody Lambert Eaton myasthenic syndrome antigen B Antibody Lambert-Eaton myasthenic syndrome antigen B Antibody MGC129334 Antibody MGC129335 Antibody Myasthenic (Lambert Eaton) syndrome antigen B Antibody Myasthenic syndrome antigen B Antibody MYSB Antibody Voltage dependent L type calcium channel subunit beta 2 Antibody Voltage-dependent L-type calcium channel subunit beta-2 Antibody
Information:	Target information shown above is from the UniProt Consortium.