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Anti-CACNA1E Antibody

品牌：Antibodies

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规格：100µl

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Anti-CACNA1E Antibody

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Overview

Name:	Anti-CACNA1E Antibody See all CACNA1E primary antibodies
Description:	Rabbit polyclonal antibody to CACNA1E
Specificity:	The antibody detects endogenous levels of total CACNA1E protein.
Applications:	IHC
Reactivity:	Human
Immunogen:	Synthetic peptide corresponding to a region derived from internal residues of human calcium channel, voltage-dependent, R type, alpha 1E subunit
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	Antigen affinity purification.
Concentration:	1.2mg / ml
Formulation:	Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
Storage:	Store at -20?C

Target

Function:	Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1E gives rise to R-type calcium currents. R-type calcium channels belong to the 'high-voltage activated' (HVA) group and are blocked by nickel, and partially by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to dihydropyridines (DHP), omega-conotoxin-GVIA (omega-CTx-GVIA), and omega-agatoxin-IVA (omega-Aga-IVA). Calcium channels containing alpha-1E subunit could be involved in the modulation of firing patterns of neurons which is important for information processing.
Tissue Specificity:	Expressed in neuronal tissues and in kidney.
Sequence Similarities:	Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1E subfamily.
Cellular Location:	Membrane.
Synonyms:	alpha-1 polypeptide Antibody BII Antibody Brain calcium channel II Antibody CAC 1E Antibody CAC1E Antibody CAC1E_HUMAN Antibody CACH 6 Antibody CACH6 Antibody CACNA1E Antibody Cacnl1 a6 Antibody CACNL1A6 Antibody Calcium channel Antibody Calcium channel, L type, alpha 1 polypeptide, isoform 6 Antibody calcium channel, R type Antibody Cav 2.3 Antibody Cav2.3 Antibody Cchra 1 Antibody Cchra1 Antibody isoform 6 Antibody L type Antibody Voltage dependent R type calcium channel subunit alpha 1E Antibody Voltage gated calcium channel subunit alpha Cav2.3 Antibody Voltage-dependent R-type calcium channel subunit alpha-1E Antibody Voltage-gated calcium channel subunit alpha Cav2.3 Antibody
Information:	Target information shown above is from the UniProt Consortium.