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Anti-CACNA1C Antibody

品牌：Antibodies

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规格：100µl

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Anti-CACNA1C Antibody

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Overview

Name:	Anti-CACNA1C Antibody See all CACNA1C primary antibodies
Description:	Rabbit polyclonal antibody to CACNA1C
Specificity:	The antibody detects endogenous levels of total CACNA1C protein.
Applications:	IHC
Reactivity:	Human
Immunogen:	Synthetic peptide corresponding to a region derived from internal residues of human calcium channel, voltage-dependent, L type, alpha 1C subunit
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	Antigen affinity purification.
Concentration:	2.2mg / ml
Formulation:	Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
Storage:	Store at -20?C

Target

Function:	Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1C gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to omega-conotoxin-GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA). Calcium channels containing the alpha-1C subunit play an important role in excitation-contraction coupling in the heart. The various isoforms display marked differences in the sensitivity to DHP compounds. Binding of calmodulin or CABP1 at the same regulatory sites results in an opposit effects on the channel function.
Tissue Specificity:	Expressed in brain, heart, jejunum, ovary, pancreatic beta-cells and vascular smooth muscle. Overall expression is reduced in atherosclerotic vascular smooth muscle.
Involvement in Disease:	Timothy syndrome: Disorder characterized by multiorgan dysfunction including lethal arrhythmias, webbing of fingers and toes, congenital heart disease, immune deficiency, intermittent hypoglycemia, cognitive abnormalities and autism. Brugada syndrome 3: A heart disease characterized by the association of Brugada syndrome with shortened QT intervals. Brugada syndrome is a tachyarrhythmia characterized by right bundle branch block and ST segment elevation on an electrocardiogram (ECG). It can cause the ventricles to beat so fast that the blood is prevented from circulating efficiently in the body. When this situation occurs, the individual will faint and may die in a few minutes if the heart is not reset.
Sequence Similarities:	Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1C subfamily.
Post-Translational Modification:	Phosphorylation by PKA activates the channel.
Cellular Location:	Membrane. Cell membrane. The interaction between RRAD and CACNB2 regulates its trafficking to the cell membrane.
Database Links:	Entrez Gene: 775?Human Omim: 114205?Human SwissProt: Q13936?Human Unigene: 118262?Human Unigene: 690010?Human
Synonyms:	alpha-1 polypeptide Antibody cardiac muscle Antibody isoform 1 Antibody L type Antibody CAC1C_HUMAN Antibody CACH 2 Antibody CACH2 Antibody CACN 2 Antibody CACN2 Antibody CACNA1C Antibody CACNA1C/CaV1.2 Antibody CACNL1A1 Antibody Calcium channel Antibody Calcium channel cardic dihydropyridine sensitive alpha 1 subunit Antibody Calcium channel L type alpha 1 polypeptide isoform 1 cardiac muscle Antibody Calcium channel voltage dependent L type alpha 1C subunit Antibody CaV1.2 Antibody CCHL1A1 Antibody DHPR alpha 1 Antibody DHPR alpha 1 subunit Antibody LQT8 Antibody TS Antibody Voltage dependent L type calcium channel alpha 1C subunit Antibody Voltage dependent L type calcium channel subunit alpha 1C Antibody Voltage gated calcium channel alpha subunit Cav1.2 Antibody Voltage gated calcium channel subunit alpha Cav1.2 Antibody Voltage gated L type calcium channel Cav1.2 alpha 1 subunit, splice variant 10* Antibody Voltage-dependent L-type calcium channel subunit alpha-1C Antibody Voltage-gated calcium channel subunit alpha Cav1.2 Antibody
Information:	Target information shown above is from the UniProt Consortium.