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Anti-CACNA1A Antibody

品牌：Antibodies

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规格：100µl

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Anti-CACNA1A Antibody

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Overview

Name:	Anti-CACNA1A Antibody See all CACNA1A primary antibodies
Description:	Rabbit polyclonal antibody to CACNA1A
Specificity:	The antibody detects endogenous levels of total CACNA1A protein.
Applications:	IHC
Reactivity:	Human
Immunogen:	Synthetic peptide corresponding to a region derived from internal residues of human calcium channel, voltage-dependent, P / Q type, alpha 1A subunit
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	Antigen affinity purification.
Concentration:	1.5mg / ml
Formulation:	Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
Storage:	Store at -20?C

Target

Function:	Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q-type calcium currents. P/Q-type calcium channels belong to the 'high-voltage activated' (HVA) group and are blocked by the funnel toxin (Ftx) and by the omega-agatoxin-IVA (omega-Aga-IVA). They are however insensitive to dihydropyridines (DHP), and omega-conotoxin-GVIA (omega-CTx-GVIA).
Tissue Specificity:	Brain specific; mainly found in cerebellum, cerebral cortex, thalamus and hypothalamus. Expressed in the small cell lung carcinoma cell line SCC-9. No expression in heart, kidney, liver or muscle. Purkinje cells contain predominantly P-type VSCC, the Q-type being a prominent calcium current in cerebellar granule cells.
Involvement in Disease:	Spinocerebellar ataxia 6: Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA6 is an autosomal dominant cerebellar ataxia (ADCA), mainly caused by expansion of a CAG repeat in the coding region of CACNA1A. There seems to be a correlation between the repeat number and earlier onset of the disorder. Migraine, familial hemiplegic, 1: A subtype of migraine with aura associated with ictal hemiparesis and, in some families, cerebellar ataxia and atrophy. Migraine is a disabling symptom complex of periodic headaches, usually temporal and unilateral. Headaches are often accompanied by irritability, nausea, vomiting and photophobia, preceded by constriction of the cranial arteries. Migraine with aura is characterized by recurrent attacks of reversible neurological symptoms (aura) that precede or accompany the headache. Aura may include a combination of sensory disturbances, such as blurred vision, hallucinations, vertigo, numbness and difficulty in concentrating and speaking. Episodic ataxia 2: An autosomal dominant disorder characterized by acetozolamide-responsive attacks of ataxia, migraine-like symptoms, interictal nystagmus, and cerebellar atrophy. Epileptic encephalopathy, early infantile, 42: A form of epileptic encephalopathy, a heterogeneous group of severe childhood onset epilepsies characterized by refractory seizures, neurodevelopmental impairment, and poor prognosis. Development is normal prior to seizure onset, after which cognitive and motor delays become apparent. EIEE42 inheritance is autosomal dominant.
Sequence Similarities:	Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1A subfamily.
Cellular Location:	Cell membrane.
Database Links:	Entrez Gene: 773?Human Omim: 601011?Human SwissProt: O00555?Human
Synonyms:	APCA Antibody BI Antibody Brain calcium channel 1 Antibody Brain calcium channel I Antibody CACH4 Antibody CACN3 Antibody CACNA1A Antibody CACNL1A4 Antibody Calcium channel alpha 1A subunit Antibody Calcium channel L type alpha 1 polypeptide Antibody Calcium channel L type alpha 1 polypeptide isoform 4 Antibody Calcium channel voltage dependent, P/Q type alpha 1A subunit Antibody CAV2.1 Antibody EA2 Antibody FHM Antibody HPCA Antibody MHP Antibody MHP1 Antibody RAT brain class A Antibody RBA-I Antibody SCA6 Antibody Voltage dependent P/Q type calcium channel alpha 1A subunit Antibody Voltage gated calcium channel alpha subunit Cav2.1 Antibody
Information:	Target information shown above is from the UniProt Consortium.