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Anti-C12orf5 Antibody

品牌：Antibodies

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规格：100µl

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Anti-C12orf5 Antibody

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Overview

Name:	Anti-C12orf5 Antibody See all C12orf5 primary antibodies
Description:	Rabbit polyclonal antibody to C12orf5
Specificity:	The antibody detects endogenous levels of total C12orf5 protein.
Applications:	IHC
Reactivity:	Human
Immunogen:	Synthetic peptide corresponding to a region derived from internal residues of human chromosome 12 open reading frame 5
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	Antigen affinity purification.
Concentration:	2.6mg / ml
Formulation:	Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
Storage:	Store at -20?C

Target

Function:	Fructose-bisphosphatase hydrolyzing fructose-2,6-bisphosphate as well as fructose-1,6-bisphosphate (PubMed:19015259). Acts as a negative regulator of glycolysis by lowering intracellular levels of fructose-2,6-bisphosphate in a p53/TP53-dependent manner, resulting in the pentose phosphate pathway (PPP) activation and NADPH production (PubMed:16839880, PubMed:22887998). Contributes to the generation of reduced glutathione to cause a decrease in intracellular reactive oxygen species (ROS) content, correlating with its ability to protect cells from oxidative or metabolic stress-induced cell death (PubMed:16839880, PubMed:19713938, PubMed:23726973, PubMed:22887998, PubMed:23817040). Plays a role in promoting protection against cell death during hypoxia by decreasing mitochondria ROS levels in a HK2-dependent manner through a mechanism that is independent of its fructose-bisphosphatase activity (PubMed:23185017). In response to cardiac damage stress, mediates p53-induced inhibition of myocyte mitophagy through ROS levels reduction and the subsequent inactivation of BNIP3. Reduced mitophagy results in an enhanced apoptotic myocyte cell death, and exacerbates cardiac damage (By similarity). Plays a role in ***** intestinal regeneration; contributes to the growth, proliferation and survival of intestinal crypts following tissue ablation (PubMed:23726973). Plays a neuroprotective role against ischemic brain damage by enhancing PPP flux and preserving mitochondria functions (By similarity). Protects glioma cells from hypoxia- and ROS-induced cell death by inhibiting glycolysis and activating mitochondrial energy metabolism and oxygen consumption in a TKTL1-dependent and p53/TP53-independent manner (PubMed:22887998). Plays a role in cancer cell survival by promoting DNA repair through activating PPP flux in a CDK5-ATM-dependent signaling pathway during hypoxia and/or genome stress-induced DNA damage responses (PubMed:25928429). Involved in intestinal tumor progression (PubMed:23726973).
Tissue Specificity:	Expressed in the brain (PubMed:22887998). Expressed in breast tumors (PubMed:21820150). Expressed in glioblastomas (PubMed:22887998).
Sequence Similarities:	Belongs to the phosphoglycerate mutase family.
Cellular Location:	Cytoplasm. Nucleus. Mitochondrion. Translocated to the mitochondria during hypoxia in a HIF1A-dependent manner (PubMed:23185017). Colocalizes with HK2 in the mitochondria during hypoxia (PubMed:23185017). Translocated to the nucleus during hypoxia and/or genome stress-induced DNA damage responses in cancer cells (PubMed:25928429). Translocation to the mitochondria is enhanced in ischemic cortex after reperfusion and/or during oxygen and glucose deprivation (OGD)/reoxygenation insult in primary neurons (By similarity).
Database Links:	Entrez Gene: 57103?Human Omim: 610775?Human SwissProt: Q9NQ88?Human Unigene: 504545?Human
Synonyms:	6-bisphosphatase TIGAR Antibody C12ORF5 Antibody chromosome 12 open reading frame 5 Antibody FR2BP Antibody Fructose-2,6-bisphosphatase TIGAR Antibody Fructose-2,6-bisphosphate 2-phosphatase Antibody Probable fructose 2,6 bisphosphatase TIGAR Antibody Probable fructose-2 Antibody TIGAR Antibody TIGAR_HUMAN Antibody TP53 induced glycolysis and apoptosis regulator Antibody TP53 induced glycolysis regulatory phosphatase Antibody TP53-induced glycolysis and apoptosis regulator Antibody Transactivated by NS3TP2 protein Antibody
Information:	Target information shown above is from the UniProt Consortium.