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Anti-BRSK1 Antibody

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规格：100µl

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Anti-BRSK1 Antibody

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Overview

Name:	Anti-BRSK1 Antibody See all BRSK1 primary antibodies
Description:	Rabbit polyclonal antibody to BRSK1
Applications:	E, WB, IHC
Reactivity:	Human, Mouse, Rat
Immunogen:	Raised against a 28 amino acid peptide from near the carboxy terminus of human BRSK1.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	Affinity chromatography purified via peptide column
Formulation:	Supplied in PBS containing 0.02% sodium azide.
Storage:	Can be stored at -20?C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target

Function:	Serine/threonine-protein kinase that plays a key role in polarization of neurons and centrosome duplication. Phosphorylates CDC25B, CDC25C, MAPT/TAU, RIMS1, TUBG1, TUBG2 and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at 'Thr-523' and 'Ser-573'. Also regulates neuron polarization by mediating phosphorylation of WEE1 at 'Ser-642' in post-mitotic neurons, leading to down-regulate WEE1 activity in polarized neurons. Also acts as a positive regulator of centrosome duplication by mediating phosphorylation of gamma-tubulin (TUBG1 and TUBG2) at 'Ser-131', leading to translocation of gamma-tubulin and its associated proteins to the centrosome. Involved in the UV-induced DNA damage checkpoint response, probably by inhibiting CDK1 activity through phosphorylation and activation of WEE1, and inhibition of CDC25B and CDC25C (By similarity). In neurons, localizes to synaptic vesicles and plays a role in neurotransmitter release, possibly by phosphorylating RIMS1.
Tissue Specificity:	Mainly present in brain. Present in presynaptic nerve terminals (at protein level).
Sequence Similarities:	Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.
Post-Translational Modification:	Phosphorylated at Thr-189 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase and CAB39. Not phosphorylated at Thr-189 by CaMKK2. In contrast, it is phosphorylated and activated by CaMKK1. May be inactivated via dephosphorylation of Thr-189 by PP2C. May be autophosphorylated.
Cellular Location:	Cytoplasm. Nucleus. Cytoplasm > Cytoskeleton > Microtubule organizing center > Centrosome. Cell junction > Synapse. Nuclear in the absence of DNA damage. Translocated to the nucleus in response to UV- or MMS-induced DNA damage (By similarity). Localizes to synaptic vesicles in neurons.
Database Links:	Entrez Gene: 84446?Human Entrez Gene: 381979?Mouse Entrez Gene: 499073?Rat Omim: 609235?Human SwissProt: Q8TDC3?Human SwissProt: Q5RJI5?Mouse SwissProt: B2DD29?Rat Unigene: 182081?Human Unigene: 297064?Mouse
Synonyms:	BR serine/threonine kinase 1 Antibody BR serine/threonine protein kinase 1 Antibody BR serine/threonine-protein kinase 1 Antibody Brain selective kinase 1 Antibody Brain-specific serine/threonine-protein kinase 1 Antibody BRSK 1 Antibody BRSK1 Antibody BRSK1_HUMAN Antibody FLJ43009 Antibody hSAD1 Antibody KIAA1811 Antibody Protein kinase SAD1A Antibody SAD 1 Antibody SAD1 Antibody SAD1 homolog Antibody SAD1 kinase Antibody SAD1A Antibody SADB Antibody SadB kinase short isoform Antibody Serine/threonine kinase SAD B Antibody Serine/threonine-protein kinase SAD-B Antibody Synapses of Amphids Defective homolog Antibody
Information:	Target information shown above is from the UniProt Consortium.