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Anti-BRF2 Antibody

品牌：Antibodies

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规格：100µg

货期：

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Anti-BRF2 Antibody

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Name:	Anti-BRF2 Antibody See all BRF2 primary antibodies
Description:	Goat polyclonal antibody to BRF2.
Applications:	ELISA, WB
Reactivity:	Human
Immunogen:	Synthetic peptide corresponding to Human BRF2 (C terminal).
Sequence:	C-QAARQAATSVPNPP
Host:	Goat
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Unconjugated
Purification:	Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration:	100 µg at 0.5 mg/ml.
Product Form:	Liquid
Formulation:	Supplied in Tris Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 0.5% BSA.
Storage:	Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Function:	General activator of RNA polymerase III transcription. Factor exclusively required for RNA polymerase III transcription of genes with promoter elements upstream of the initiation sites (PubMed:11040218, PubMed:11121026, PubMed:11564744, PubMed:26638071). Contributes to the regulation of gene expression; functions as activator in the absence of oxidative stress (PubMed:26638071). Down-regulates expression of target genes in response to oxidative stress (PubMed:26638071). Overexpression protects cells against apoptosis in response to oxidative stress (PubMed:26638071).
Sequence Similarities:	Belongs to the TFIIB family.
Post-Translational Modification:	In response to oxidative stress, Cys-361 is reversibly oxidized to cysteine sulfenic acid. Oxidation of Cys-361 impairs formation of a ternary complex with TBP and DNA and down-regulates expression of target genes in response to oxidative stress.
Cellular Location:	Nucleus.
Database Links:	Entrez Gene: 55290 Human Omim: 607013 Human SwissProt: Q9HAW0 Human Unigene: 726335 Human
Synonyms:	B-related factor 2 Antibody BRF-2 Antibody BRF2 Antibody BRF2_HUMAN Antibody BRFU Antibody FLJ11052 Antibody hBRFU Antibody hTFIIIB50 Antibody RNA polymerase III transcription initiation factor BRF2 Antibody TFIIIB50 Antibody Transcription factor IIB- related factor TFIIIB50 Antibody Transcription factor IIIB 50 kDa subunit Antibody
Information:	Target information shown above is from the UniProt Consortium.