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Anti-BRCC45 Antibody

品牌：Antibodies

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规格：100µl

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Anti-BRCC45 Antibody

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Overview

Name:	Anti-BRCC45 Antibody See all BRCC45 primary antibodies
Description:	Rabbit polyclonal antibody to BRCC45
Applications:	E, WB, IHC
Reactivity:	Human, Mouse, Rat
Immunogen:	Raised against a 18 amino acid peptide from near the amino terminus of human BRCC45.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	Affinity chromatography purified via peptide column
Formulation:	Supplied in PBS containing 0.02% sodium azide.
Storage:	Can be stored at -20?C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target

Function:	Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it acts as an adapter that bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex integrity and modulating the E3 ubiquitin ligase activity of the BRCA1-BARD1 heterodimer. Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates. Within the BRISC complex, acts as an adapter that bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex integrity. The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1. The BRISC complex plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1; deubiquitination increases IFNAR1 activity by enhancing its stability and cell surface expression. Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in IFNAR1 deubiquitination. May play a role in homeostasis or cellular differentiation in cells of neural, epithelial and germline origins. May also act as a death receptor-associated anti-apoptotic protein, which inhibits the mitochondrial apoptotic pathway. May regulate TNF-alpha signaling through its interactions with TNFRSF1A; however these effects may be indirect.
Sequence Similarities:	Belongs to the BABAM2 family.
Cellular Location:	Cytoplasm. Nucleus. Localizes at sites of DNA damage at double-strand breaks (DSBs).
Database Links:	Entrez Gene: 9577?Human Entrez Gene: 107976?Mouse Entrez Gene: 362704?Rat Omim: 610497?Human SwissProt: Q9NXR7?Human SwissProt: Q8K3W0?Mouse SwissProt: Q6P7Q1?Rat Unigene: 258314?Human Unigene: 482126?Mouse Unigene: 224501?Rat
Synonyms:	6030405P19Rik Antibody AI429776 Antibody B830038C02Rik Antibody Brain and reproductive organ expressed (TNFRSF1A modulator) Antibody brain and reproductive organ expressed protein Antibody Brain and reproductive organ-expressed protein Antibody BRCA1 A complex subunit BRE Antibody BRCA1-A complex subunit BRE Antibody BRCA1/BRCA2 containing complex subunit 4 Antibody BRCA1/BRCA2 containing complex subunit 45 Antibody BRCA1/BRCA2-containing complex subunit 45 Antibody BRCC4 Antibody BRCC45 Antibody bre Antibody BRE_HUMAN Antibody
Information:	Target information shown above is from the UniProt Consortium.