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Anti-BNIP3 Antibody

品牌：Antibodies

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规格：100µl

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Anti-BNIP3 Antibody

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Overview

Name:	Anti-BNIP3 Antibody See all BNIP3 primary antibodies
Description:	Rabbit polyclonal antibody to BNIP3
Specificity:	The antibody detects endogenous levels of total BNIP3 protein.
Applications:	WB, IHC
Reactivity:	Human, Mouse
Immunogen:	Fusion protein corresponding to residues near the N terminal of human BCL2 / adenovirus E1B 19kDa interacting protein 3
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	Antigen affinity purification.
Concentration:	1.1mg / ml
Formulation:	Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
Storage:	Store at -20?C

Target

Function:	Apoptosis-inducing protein that can overcome BCL2 suppression. May play a role in repartitioning calcium between the two major intracellular calcium stores in association with BCL2. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates in mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. Plays an important role in the calprotectin (S100A8/A9)-induced cell death pathway.
Sequence Similarities:	Belongs to the NIP3 family.
Cellular Location:	Mitochondrion. Mitochondrion outer membrane. Coexpression with the EIB 19-kDa protein results in a shift in NIP3 localization pattern to the nuclear envelope. Colocalizes with ACAA2 in the mitochondria. Colocalizes with SPATA18 at the mitochondrion outer membrane.
Database Links:	Entrez Gene: 664?Human Entrez Gene: 12176?Mouse Omim: 603293?Human SwissProt: Q12983?Human SwissProt: O55003?Mouse Unigene: 144873?Human Unigene: 378890?Mouse
Synonyms:	BCL2 Adenovirus E1B 19kDa Interacting Protein 3 Antibody BCL2/adenovirus E1B 19 kDa protein interacting protein 3 Antibody BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 Antibody BNIP 3 Antibody BNIP3 Antibody BNIP3_HUMAN Antibody NIP 3 Antibody NIP3 Antibody
Information:	Target information shown above is from the UniProt Consortium.