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Anti-BMPR1B Antibody

品牌：Antibodies

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规格：50µl

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Anti-BMPR1B Antibody

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Overview

Name:	Anti-BMPR1B Antibody See all BMPR1B primary antibodies
Description:	Rabbit polyclonal antibody to BMPR1B
Specificity:	BMPR1B pAb detects endogenous levels of BMPR1B protein.
Applications:	WB, IHC, IF
Reactivity:	Human, Mouse
Immunogen:	Recombinant full length Human BMPR1B.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Molecular Weight:	~ 57 kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form:	1mg/ml in PBS?with?0.1%?Sodium?Azide,?50%?Glycerol.

Target

Function:	On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP7/OP-1 and GDF5. Positively regulates chondrocyte differentiation through GDF5 interaction.
Involvement in Disease:	Acromesomelic dysplasia, Demirhan type: A form of chondrodysplasia. Acromesomelic chondrodysplasias are rare hereditary skeletal disorders characterized by short stature, very short limbs and hand/foot malformations. The severity of limb abnormalities increases from proximal to distal with profoundly affected hands and feet showing brachydactyly and/or rudimentary fingers (knob-like fingers). Brachydactyly A2: A form of brachydactyly. Brachydactyly defines a group of inherited malformations characterized by shortening of the digits due to abnormal development of the phalanges and/or the metacarpals. In brachydactyly type A2 shortening of the middle phalanges is confined to the index finger and the second toe, all other digits being more or less normal. Because of a rhomboid or triangular shape of the affected middle phalanx, the end of the second finger usually deviates radially. Brachydactyly A1, D: A form of brachydactyly type A1. Brachydactyly defines a group of inherited malformations characterized by shortening of the digits due to abnormal development of the phalanges and/or the metacarpals. Brachydactyly type A1 is characterized by middle phalanges of all the digits rudimentary or fused with the terminal phalanges. The proximal phalanges of the thumbs and big toes are short. BDA1D inheritance is autosomal dominant.
Sequence Similarities:	Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
Cellular Location:	Cell membrane. Membrane.
Synonyms:	Activin receptor like kinase 6 Antibody Acvrlk6 Antibody ALK 6 Antibody ALK6 Antibody alk6tr Antibody BMP type-1B receptor Antibody BMPR IB Antibody BMPR-1B Antibody BMPR1B Antibody BMPRIB Antibody BMR1B_HUMAN Antibody Bone morphogenetic protein receptor type 1B Antibody Bone morphogenetic protein receptor type IB Antibody Bone morphogenetic protein receptor type-1B Antibody BR 1b Antibody BR1b Antibody CDw 293 Antibody CDw293 Antibody CDw293 antigen Antibody CFK 43a Antibody CFK43a Antibody Serine/threonine receptor kinase Antibody zALK 6 Antibody zALK6 Antibody
Information:	Target information shown above is from the UniProt Consortium.