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Anti-BMP-2 Antibody

品牌：Antibodies

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规格：50µl

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Anti-BMP-2 Antibody

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Name:	Anti-BMP-2 Antibody See all BMP-2 primary antibodies
Description:	Rabbit polyclonal antibody to BMP-2
Specificity:	BMP-2 Polyclonal Antibody detects endogenous levels of BMP-2 protein.
Applications:	WB, IHC, ELISA
Reactivity:	Human, Mouse, Rat
Immunogen:	Synthesized peptide derived from the Internal region of human BMP-2.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:	1mg / ml
Formulation:	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Storage:	Store at -20?C / 1 year

Function:	Induces cartilage and bone formation (PubMed:3201241). Stimulates the differentiation of myoblasts into osteoblasts via the EIF2AK3-EIF2A- ATF4 pathway. BMP2 activation of EIF2AK3 stimulates phosphorylation of EIF2A which leads to increased expression of ATF4 which plays a central role in osteoblast differentiation. In addition stimulates TMEM119, which upregulates the expression of ATF4 (PubMed:24362451).
Tissue Specificity:	Particularly abundant in lung, spleen and colon and in low but significant levels in heart, brain, placenta, liver, skeletal muscle, kidney, pancreas, prostate, ovary and small intestine.
Sequence Similarities:	Belongs to the TGF-beta family.
Cellular Location:	Secreted.
Database Links:	Entrez Gene: 650?Human Entrez Gene: 12156?Mouse Entrez Gene: 29373?Rat Omim: 112261?Human SwissProt: P12643?Human SwissProt: P21274?Mouse SwissProt: P49001?Rat Unigene: 73853?Human Unigene: 103205?Mouse Unigene: 90931?Rat
Synonyms:	BDA2 Antibody BMP-2 Antibody BMP-2A Antibody BMP2 Antibody BMP2A Antibody BMP2_HUMAN Antibody Bone morphogenetic protein 2 Antibody Bone morphogenetic protein 2A Antibody
Information:	Target information shown above is from the UniProt Consortium.