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Anti-BLM Antibody

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规格：100µl

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Anti-BLM Antibody

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Overview

Name:	Anti-BLM Antibody See all BLM primary antibodies
Description:	Rabbit polyclonal antibody to BLM
Specificity:	The antibody detects endogenous levels of total BLM protein.
Applications:	IF, WB
Reactivity:	Human
Immunogen:	Recombinant fragment corresponding to a region within amino acids 30 and 385 of BLM.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	Antibodies were purified by antigen-affinity chromatography.
Concentration:	0.93mg / ml
Formulation:	Rabbit IgG in 1XPBS, 20% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Storage:	Store at -20˚C

Target

Function:	Participates in DNA replication and repair. Exhibits a magnesium-dependent ATP-dependent DNA-helicase activity that unwinds single- and double-stranded DNA in a 3'-5' direction. Involved in 5'-end resection of DNA during double-strand break (DSB) repair: unwinds DNA and recruits DNA2 which mediates the cleavage of 5'-ssDNA. Negatively regulates sister chromatid exchange (SCE).
Involvement in Disease:	Bloom syndrome: An autosomal recessive disorder. It is characterized by proportionate pre- and postnatal growth deficiency, sun-sensitive telangiectatic hypo- and hyperpigmented skin, predisposition to malignancy, and chromosomal instability.
Sequence Similarities:	Belongs to the helicase family. RecQ subfamily.
Post-Translational Modification:	Phosphorylated in response to DNA damage. Phosphorylation requires the FANCA-FANCC-FANCE-FANCF-FANCG protein complex, as well as the presence of RMI1.
Cellular Location:	Nucleus. Together with SPIDR, is redistributed in discrete nuclear DNA damage-induced foci following hydroxyurea (HU) or camptothecin (CPT) treatment. Accumulated at sites of DNA damage in a RMI complex- and SPIDR-dependent manner.
Database Links:	Entrez Gene: 641 Human Omim: 604610 Human SwissProt: P54132 Human Unigene: 725208 Human
Synonyms:	Blm Antibody BLM_HUMAN Antibody Bloom syndrome Antibody Bloom syndrome protein Antibody Bloom syndrome RecQ helicase like Antibody Blooms Syndrome Protein Blm Antibody BS Antibody DNA helicase Antibody DNA helicase RecQ like type 2 Antibody MGC126616 Antibody MGC131618 Antibody MGC131620 Antibody RECQ 2 Antibody RECQ like Antibody RecQ like type 2 Antibody RecQ protein like 3 Antibody RecQ protein-like 3 Antibody RecQ-like type 2 Antibody RecQ2 Antibody RECQL 2 Antibody RECQL 3 Antibody RECQL2 Antibody RECQL3 Antibody type 2 Antibody
Information:	Target information shown above is from the UniProt Consortium.