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Anti-Blimp-1 Antibody

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规格：100µl

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Anti-Blimp-1 Antibody

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Overview

Name:	Anti-Blimp-1 Antibody See all Blimp-1 primary antibodies
Description:	Rabbit polyclonal antibody to Blimp-1
Applications:	E, WB, IHC
Reactivity:	Human, Mouse, Rat
Immunogen:	Raised against a 17 amino acid peptide from near the amino terminus of human Blimp-1.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	Affinity chromatography purified via peptide column
Formulation:	Supplied in PBS containing 0.02% sodium azide.
Storage:	Can be stored at -20?C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target

Function:	Transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs (PubMed:27102484). Plays a role in the development, retention and long-term establishment of adaptive and innate tissue-resident lymphocyte T cell types in non-lymphoid organs, such as the skin and gut, but also in other nonbarrier tissues like liver and kidney, and therefore may provide immediate immunological protection against reactivating infections or viral reinfection (PubMed:27102484). Binds specifically to the PRDI element in the promoter of the beta-interferon gene (By similarity). Drives the maturation of B-lymphocytes into Ig secreting cells (By similarity). Associates with the transcriptional repressor ZNF683 to chromatin at gene promoter regions (PubMed:27102484).
Tissue Specificity:	Expressed in innate lymphocytes, including tissue-resident conventional natural killer (cNK) cells in liver (PubMed:27102484). Expressed also weakly in tissue-resident natural killer (trNK) and natural killer T (NKT) cells in liver (PubMed:27102484). Isoform 1 is detected in bone marrow, spleen and lymph node but not in brain, heart, kidney, liver, ovary or muscle. Weak expression detected in the lung. Isoform 3 is detected only in yolk sac. Isoform 4 is detected in embryo, yolk sac, placenta, splenocytes, and activated T-cells.
Sequence Similarities:	Belongs to the class V-like SAM-binding methyltransferase superfamily.
Post-Translational Modification:	Sumoylation at Lys-847 by PIAS1 augments transcriptional repressor activity, and is critical for plasma cell differentiation.
Cellular Location:	Nucleus. Cytoplasm.
Database Links:	Entrez Gene: 639?Human Entrez Gene: 12142?Mouse Entrez Gene: 309871?Rat Omim: 603423?Human SwissProt: O75626?Human SwissProt: Q60636?Mouse Unigene: 436023?Human Unigene: 4800?Mouse Unigene: 8012?Rat
Synonyms:	B Lymphocyte Induced Maturation Protein 1 Antibody Beta interferon gene positive regulatory domain I binding factor Antibody Beta-interferon gene positive regulatory domain I-binding factor Antibody BLIMP-1 Antibody BLIMP1 Antibody Positive Regulatory Domain I Binding Factor 1 Antibody Positive regulatory domain I-binding factor 1 Antibody PR Domain Containing 1 Antibody PR domain containing 1 with ZNF domain Antibody PR domain containing 1 with ZNF domain isoform 2 Antibody PR domain containing protein 1 Antibody PR domain zinc finger protein 1 Antibody PR domain-containing protein 1 Antibody PRDI BF1 Antibody PRDI binding factor 1 Antibody PRDI-BF1 Antibody PRDI-binding factor 1 Antibody PRDM 1 Antibody Prdm1 Antibody PRDM1/Blimp1 Antibody PRDM1_HUMAN Antibody
Information:	Target information shown above is from the UniProt Consortium.