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Anti-BIN1 Antibody

品牌：Antibodies

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规格：50µl

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Anti-BIN1 Antibody

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Overview

Name:	Anti-BIN1 Antibody See all BIN1 primary antibodies
Description:	Rabbit polyclonal antibody to BIN1
Specificity:	BIN1 pAb detects endogenous levels of BIN1 protein.
Applications:	WB, IHC, IF
Reactivity:	Human, Mouse, Rat
Immunogen:	Recombinant full length Human BIN1.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Molecular Weight:	~ 65 kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form:	1mg/ml in PBS?with?0.1%?Sodium?Azide,?50%?Glycerol.

Target

Function:	May be involved in regulation of synaptic vesicle endocytosis. May act as a tumor suppressor and inhibits malignant cell transformation.
Tissue Specificity:	Ubiquitous. Highest expression in the brain and muscle. Isoform IIA is expressed only in the brain where it is concentrated in axon initial segments and nodes of Ranvier. Isoform BIN1 is widely expressed with highest expression in skeletal muscle.
Involvement in Disease:	Myopathy, centronuclear, 2: A congenital muscle disorder characterized by progressive muscular weakness and wasting involving mainly limb girdle, trunk, and neck muscles. It may also affect distal muscles. Weakness may be present during childhood or adolescence or may not become evident until the third decade of life. Ptosis is a frequent clinical feature. The most prominent histopathologic features include high frequency of centrally located nuclei in muscle fibers not secondary to regeneration, radial arrangement of sarcoplasmic strands around the central nuclei, and predominance and hypotrophy of type 1 fibers.
Post-Translational Modification:	Phosphorylated by protein kinase C.
Cellular Location:	Nucleus.
Database Links:	Entrez Gene: 274?Human Entrez Gene: 30948?Mouse Entrez Gene: 117028?Rat Omim: 601248?Human SwissProt: O00499?Human SwissProt: O08539?Mouse SwissProt: O08839?Rat Unigene: 193163?Human Unigene: 4383?Mouse Unigene: 17098?Rat
Synonyms:	AMPH 2 Antibody AMPH2 Antibody Amphiphysin 2 Antibody Amphiphysin II Antibody Amphiphysin like protein Antibody amphiphysin-like Antibody Amphiphysin-like protein Antibody AMPHL Antibody BIN1 Antibody BIN1_HUMAN Antibody Box Dependant MYC Interacting Protein 1 Antibody Box-dependent myc-interacting protein 1 Antibody Bridging integrator 1 Antibody DKFZp547F068 Antibody MGC10367 Antibody MGC105358 Antibody Myc box dependent interacting protein 1 Antibody Myc box-dependent-interacting protein 1 Antibody SH3P9 Antibody
Information:	Target information shown above is from the UniProt Consortium.