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Anti-BIM (Phospho-Ser69) Antibody

品牌：Antibodies

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规格：50µl

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Anti-BIM (Phospho-Ser69) Antibody

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Overview

Name:	Anti-BIM (Phospho-Ser69) Antibody See all BIM primary antibodies
Description:	Rabbit polyclonal antibody to BIM (Phospho-Ser69)
Specificity:	The antibody detects endogenous level of BIM only when phosphorylated at serine 69.
Applications:	IHC, IF
Reactivity:	Human, Mouse, Rat
Immunogen:	Peptide sequence around phosphorylation site of serine 69 (P-A-S(p)-P-G) derived from Human BIM.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Concentration:	1.0mg / ml
Formulation:	Supplied at 1.0mg / mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage:	Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.

Target

Function:	Induces apoptosis and anoikis. Isoform BimL is more potent than isoform BimEL. Isoform Bim-alpha1, isoform Bim-alpha2 and isoform Bim-alpha3 induce apoptosis, although less potent than isoform BimEL, isoform BimL and isoform BimS. Isoform Bim-gamma induces apoptosis. Isoform Bim-alpha3 induces apoptosis possibly through a caspase-mediated pathway. Isoform BimAC and isoform BimABC lack the ability to induce apoptosis.
Tissue Specificity:	Isoform BimEL, isoform BimL and isoform BimS are the predominant isoforms and are widely expressed with tissue-specific variation. Isoform Bim-gamma is most abundantly expressed in small intestine and colon, and in lower levels in spleen, prostate, testis, heart, liver and kidney.
Sequence Similarities:	Belongs to the Bcl-2 family.
Post-Translational Modification:	Phosphorylation at Ser-69 by MAPK1/MAPK3 leads to interaction with TRIM2 and polyubiquitination, followed by proteasomal degradation (PubMed:15486195, PubMed:21478148). Deubiquitination catalyzed by USP27X stabilizes the protein (By similarity).
Cellular Location:	Endomembrane system. Associated with intracytoplasmic membranes.
Database Links:	Entrez Gene: 10018?Human Entrez Gene: 12125?Mouse Entrez Gene: 64547?Rat Omim: 603827?Human SwissProt: O43521?Human SwissProt: O54918?Mouse SwissProt: O88498?Rat Unigene: 469658?Human Unigene: 141083?Mouse Unigene: 453214?Mouse Unigene: 82709?Rat
Synonyms:	BCL2 like 11 Antibody B2L11_HUMAN Antibody BAM Antibody Bcl 2 interacting protein Bim Antibody Bcl 2 related ovarian death agonist Antibody Bcl-2-like protein 11 Antibody BCL2 interacting mediator of cell death Antibody BCL2 like 11 (apoptosis facilitator) Antibody BCL2 like protein 11 Antibody Bcl2-interacting mediator of cell death Antibody Bcl2-L-11 Antibody Bcl2l11 Antibody Bim Antibody BIM alpha6 Antibody BIM beta6 Antibody BIM beta7 Antibody BimEL Antibody BimL Antibody BOD Antibody
Information:	Target information shown above is from the UniProt Consortium.