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Anti-BICD2 Antibody

品牌：Antibodies

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规格：100µl

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Anti-BICD2 Antibody

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Overview

Name:	Anti-BICD2 Antibody See all BICD2 primary antibodies
Description:	Rabbit polyclonal antibody to BICD2
Specificity:	The antibody detects endogenous levels of total BICD2 protein.
Applications:	IHC
Reactivity:	Human
Immunogen:	Synthetic peptide of human BICD2
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	Antigen affinity purification
Concentration:	1.7mg / ml
Formulation:	Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
Storage:	Store at -20?C

Target

Function:	Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates and stabilizes the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track) (By similarity). Facilitates the binding of RAB6A to the Golgi by stabilizing its GTP-bound form. Regulates coat complex coatomer protein I (COPI)-independent Golgi-endoplasmic reticulum transport via its interaction with RAB6A and recruitment of the dynein-dynactin motor complex (PubMed:25962623). Contributes to nuclear and centrosomal positioning prior to mitotic entry through regulation of both dynein and kinesin-1. During G2 phase of the cell cycle, associates with RANBP2 at the nuclear pores and recruits dynein and dynactin to the nuclear envelope to ensure proper positioning of the nucleus relative to centrosomes prior to the onset of mitosis (By similarity).
Tissue Specificity:	Ubiquitous.
Involvement in Disease:	Spinal muscular atrophy, lower extremity-predominant 2, autosomal dominant: An autosomal dominant form of spinal muscular atrophy characterized by early-childhood onset of muscle weakness and atrophy predominantly affecting the proximal and distal muscles of the lower extremity, although some patients may show upper extremity involvement. The disorder results in delayed walking, waddling gait, difficulty walking, and loss of distal reflexes. Some patients may have foot deformities or hyperlordosis, and some show mild upper motor signs, such as spasticity. Sensation, bulbar function, and cognitive function are preserved. The disorder shows very slow progression throughout life.
Sequence Similarities:	Belongs to the BicD family.
Post-Translational Modification:	Phosphorylated by NEK9 in vitro.
Cellular Location:	Golgi apparatus. Cytoplasm > Cytoskeleton. Cytoplasm. Nucleus envelope. Nucleus > Nuclear pore complex. In interphase cells mainly localizes to the Golgi complex and colocalizes with dynactin at microtubule plus ends (By similarity). Localizes to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae in a RANBP2-dependent manner during G2 phase of the cell cycle (PubMed:20386726).
Database Links:	Entrez Gene: 23299?Human Omim: 609797?Human SwissProt: Q8TD16?Human Unigene: 436939?Human
Synonyms:	bA526D8.1 Antibody Bic D 2 Antibody Bic-D 2 Antibody Bicaudal D homolog 2 Antibody Bicaudal D homolog 2 (Drosophila) Antibody BICD2 Antibody BICD2_HUMAN Antibody Coiled coil protein BICD2 Antibody Cytoskeleton like bicaudal D protein homolog 2 Antibody Homolog of Drosophila bicaudal D Antibody KIAA0699 Antibody Protein bicaudal D homolog 2 Antibody
Information:	Target information shown above is from the UniProt Consortium.