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Anti-BCL11A Antibody

品牌：Antibodies

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规格：50µl

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Anti-BCL11A Antibody

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Overview

Name:	Anti-BCL11A Antibody See all BCL11A primary antibodies
Description:	Rabbit polyclonal antibody to BCL11A.
Applications:	WB, IHC
Dilutions:	WB: 1:500 - 1:2000, IHC: 1:50 - 1:200.
Reactivity:	Human, Mouse, Rat
Immunogen:	Recombinant protein of human BCL11A.
Protein Length:	835 (773)
Host:	Rabbit
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Unconjugated
Purification:	Affinity purification.
Product Form:	Liquid
Formulation:	Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage:	Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Target

Function:	Transcription factor associated with the BAF SWI/SNF chromatin remodeling complex (By similarity). Repressor of fetal hemoglobin (HbF) level (PubMed:26375765). Involved in brain development (PubMed:27453576). Functions as a myeloid and B-cell proto-oncogene. May play important roles in leukemogenesis and hematopoiesis. Essential factor in lymphopoiesis required for B-cell formation in fetal liver. May function as a modulator of the transcriptional repression activity of ARP1 (By similarity).
Tissue Specificity:	Expressed at high levels in brain, spleen thymus, bone marrow and testis. Expressed in CD34-positive myeloid precursor cells, B-cells, monocytes and megakaryocytes. Expression is tightly regulated during B-cell development.
Involvement in Disease:	Intellectual developmental disorder with persistence of fetal hemoglobin: An autosomal dominant disorder characterized by delayed psychomotor development, intellectual disability, variable dysmorphic features, including microcephaly, downslanting palpebral fissures, strabismus, and external ear abnormalities, and asymptomatic persistence of fetal hemoglobin.
Post-Translational Modification:	Sumoylated with SUMO1.
Cellular Location:	Cytoplasm. Nucleus. Associates with the nuclear body. Colocalizes with SUMO1 and SENP2 in nuclear speckles (By similarity).
Database Links:	Entrez Gene: 53335?Human Entrez Gene: 14025?Mouse Entrez Gene: 305589?Rat Omim: 606557?Human SwissProt: Q9H165?Human SwissProt: Q9QYE3?Mouse Unigene: 370549?Human Unigene: 441102?Mouse Unigene: 471050?Mouse Unigene: 53687?Mouse Unigene: 88824?Mouse Unigene: 16729?Rat
Synonyms:	2810047E18Rik Antibody B cell CLL/lymphoma 11A (zinc finger protein) Antibody B cell CLL/lymphoma 11A (zinc finger protein) isoform 2 Antibody B-cell CLL/lymphoma 11A Antibody B-cell lymphoma/leukemia 11A Antibody BC11A_HUMAN Antibody BCL-11A Antibody BCL11A Antibody BCL11A B cell CLL/lymphoma 11A (zinc finger protein) isoform 1 Antibody BCL11A L Antibody BCL11A S Antibody BCL11A XL Antibody BCL11a-M Antibody BCL11AL Antibody BCL11AS Antibody BCL11AXL Antibody C2H2 type zinc finger protein Antibody COUP TF interacting protein 1 Antibody COUP-TF-interacting protein 1 Antibody Ctip1 Antibody CTIP1, mouse, homolog of Antibody D930021L15Rik Antibody Ecotropic viral integration site 9 Antibody Ecotropic viral integration site 9 homolog Antibody Ecotropic viral integration site 9 protein Antibody Ecotropic viral integration site 9 protein homolog Antibody EVI-9 Antibody Evi9 Antibody Evi9, mouse, homolog of Antibody FLJ10173 Antibody FLJ34997 Antibody HBFQTL5 Antibody KIAA1809 Antibody mKIAA1809 Antibody OTTHUMP00000159788 Antibody OTTHUMP00000159789 Antibody OTTHUMP00000201250 Antibody OTTHUMP00000202084 Antibody Zinc finger protein 856 Antibody ZNF856 Antibody
Information:	Target information shown above is from the UniProt Consortium.