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Anti-BCKDK (E41) Antibody

品牌：Antibodies

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规格：50µl

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Anti-BCKDK (E41) Antibody

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Name:	Anti-BCKDK (E41) Antibody See all BCKDK primary antibodies
Description:	Rabbit polyclonal antibody to BCKDK (E41)
Specificity:	BCKDK (E41) pAb detects endogenous levels of BCKDK protein.
Applications:	WB, IHC
Reactivity:	Human, Mouse, Rat
Immunogen:	Synthetic peptide, corresponding to amino acids 21-70 of Human BCKDK.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Molecular Weight:	~ 46 kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form:	1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.

Function:	Catalyzes the phosphorylation and inactivation of the branched-chain alpha-ketoacid dehydrogenase complex, the key regulatory enzyme of the valine, leucine and isoleucine catabolic pathways. Key enzyme that regulate the activity state of the BCKD complex.
Tissue Specificity:	Ubiquitous.
Involvement in Disease:	Branched-chain ketoacid dehydrogenase kinase deficiency: A metabolic disorder characterized by autism, epilepsy, intellectual disability, and reduced branched-chain amino acids.
Sequence Similarities:	Belongs to the PDK/BCKDK protein kinase family.
Post-Translational Modification:	Autophosphorylated.
Cellular Location:	Mitochondrion matrix. Mitochondrion.
Database Links:	Entrez Gene: 10295?Human Entrez Gene: 12041?Mouse Entrez Gene: 29603?Rat Omim: 614901?Human SwissProt: O14874?Human SwissProt: O55028?Mouse SwissProt: Q00972?Rat Unigene: 513520?Human Unigene: 425495?Mouse Unigene: 31976?Rat
Synonyms:	BCKD kinase Antibody BCKD-kinase Antibody BCKDH kinase Antibody BCKDHKIN Antibody Bckdk Antibody BCKDKD Antibody BCKD_HUMAN Antibody BDK Antibody Branched chain alpha keto acid dehydrogenase kinase Antibody Branched chain ketoacid dehydrogenase kinase Antibody Branched-chain alpha-ketoacid dehydrogenase kinase Antibody mitochondrial Antibody [3 methyl 2 oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial Antibody [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase Antibody
Information:	Target information shown above is from the UniProt Consortium.