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Anti-BAT3 Antibody

品牌：Antibodies

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规格：100µg

货期：

应用：

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Anti-BAT3 Antibody

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Overview

Name:	Anti-BAT3 Antibody See all BAT3 primary antibodies
Description:	Goat polyclonal antibody to BAT3.
Applications:	ELISA, IHC
Reactivity:	Human
Immunogen:	Synthetic peptide corresponding to Human BAT3 (internal region).
Sequence:	C-PETNAPNHPSPAEY
Host:	Goat
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Unconjugated
Purification:	Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration:	100 μg at 0.5 mg/ml.
Product Form:	Liquid
Formulation:	Supplied in Tris Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 0.5% BSA.
Storage:	Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Target

Function:	Chaperone that plays a key role in various processes such as apoptosis, insertion of tail-anchored (TA) membrane proteins to the endoplasmic reticulum membrane and regulation of chromatin. Key component of the BAG6/BAT3 complex, a cytosolic multiprotein complex involved in the post-translational delivery of tail-anchored (TA) membrane proteins to the endoplasmic reticulum membrane (PubMed:20516149, PubMed:20676083). TA membrane proteins, also named type II transmembrane proteins, contain a single C-terminal transmembrane region. BAG6/BAT3 acts by facilitating TA membrane proteins capture by ASNA1/TRC40: it is recruited to ribosomes synthesizing membrane proteins, interacts with the transmembrane region of newly released TA proteins and transfers them to ASNA1/TRC40 for targeting to the endoplasmic reticulum membrane (PubMed:20516149, PubMed:20676083). Moreover, it regulates the stability and the degradation of proteins by the proteasome: for instance, it is required for selective ubiquitin-mediated degradation of defective nascent chain polypeptides by the proteasome (By similarity). In this context, may play a role in immuno-proteasomes to generate antigenic peptides via targeted degradation, thereby playing a role in antigen presentation in immune response (By similarity). It is also involved in ubiquitin-mediated proteasomal degradation of proteins of the secretory pathway that are mislocalized to the cytosol (PubMed:23129660, PubMed:25179605, PubMed:27193484). Binds the mislocalized proteins, preventing their aggregation in the cytosol, and promotes their ubiquitination via interaction with RNF126 (PubMed:24981174). Interaction with SGTA prevents recruitment of RNF126, thereby preventing ubiquitination and counteracting BAG6-dependent degradation of proteins (PubMed:23129660, PubMed:25179605, PubMed:27193484). Participates in endoplasmic reticulum stress-induced apoptosis via its interaction with AIFM1/AIF by regulating AIFM1/AIF stability and preventing its degradation (By similarity). Also required during spermatogenesis for synaptonemal complex assembly via its interaction with HSPA2, by inhibiting polyubiquitination and subsequent proteasomal degradation of HSPA2 (By similarity).
Post-Translational Modification:	Cleavage by caspase-3 releases a C-terminal peptide that plays a role in ricin-induced apoptosis.
Cellular Location:	Cytoplasm > Cytosol. Nucleus. The C-terminal fragment generated by caspase-3 is cytoplasmic. Also found in extracellular vesicular exosomes in some tumor cells.
Database Links:	Entrez Gene: 7917?Human Omim: 142590?Human SwissProt: P46379?Human Unigene: 440900?Human
Synonyms:	2410045D21Rik Antibody AA408914 Antibody BAG 6 Antibody BAG family molecular chaperone regulator 6 Antibody BAG-6 Antibody BAG6 Antibody BAG6_HUMAN Antibody BAT 3 Antibody BAT3 Antibody BCL2-associated athanogene 6 Antibody D17H6S52E Antibody D6S52E Antibody G3 Antibody HLA B associated transcript 3 Antibody HLA-B associated transcript 3 Antibody HLA-B associated transcript-3 Antibody HLA-B-associated transcript 3 Antibody large proline rich protein BAG6 Antibody Large proline rich protein BAT3 Antibody Large proline-rich protein BAG6 Antibody large proline-rich protein BAT3 Antibody Protein G3 Antibody Protein Scythe Antibody Scythe Antibody Scythe, homolog of Xenopus Antibody
Information:	Target information shown above is from the UniProt Consortium.