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Anti-BAT Antibody

品牌：Antibodies

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规格：100µl

货期：

应用：

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Anti-BAT Antibody

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Overview

Name:	Anti-BAT Antibody See all BAT primary antibodies
Description:	Rabbit polyclonal antibody to BAT
Applications:	WB, IHC
Reactivity:	Human
Immunogen:	Recombinant protein fragment contain a sequence corresponding to a region within amino acids 139 and 385 of BAT
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	Purified by antigen-affinity chromatography.
Formulation:	Supplied in 0.1M Tris-buffered saline with 10% Glycerol (pH7.0). 0.01% Thimerosal was added as a preservative.
Storage:	Store at -20?C for long term preservation (recommended). Store at 4?C for short term use.

Target

Function:	Involved in bile acid metabolism. In liver hepatocytes catalyzes the second step in the conjugation of C24 bile acids (choloneates) to glycine and taurine before excretion into bile canaliculi. The major components of bile are cholic acid and chenodeoxycholic acid. In a first step the bile acids are converted to an acyl-CoA thioester, either in peroxisomes (primary bile acids deriving from the cholesterol pathway), or cytoplasmic at the endoplasmic reticulum (secondary bile acids). May catalyze the conjugation of primary or secondary bile acids, or both. The conjugation increases the detergent properties of bile acids in the intestine, which facilitates lipid and fat-soluble vitamin absorption. In turn, bile acids are deconjugated by bacteria in the intestine and are recycled back to the liver for reconjugation (secondary bile acids). May also act as an acyl-CoA thioesterase that regulates intracellular levels of free fatty acids. In vitro, catalyzes the hydrolysis of long- and very long-chain saturated acyl-CoAs to the free fatty acid and coenzyme A (CoASH), and conjugates glycine to these acyl-CoAs.
Tissue Specificity:	Expressed in liver, gallbladder mucosa and pancreas.
Involvement in Disease:	Familial hypercholanemia: A disorder characterized by elevated serum bile acid concentrations, itching, and fat malabsorption.
Sequence Similarities:	Belongs to the C/M/P thioester hydrolase family.
Cellular Location:	Cytoplasm.
Database Links:	Entrez Gene: 570?Human Omim: 602938?Human SwissProt: Q14032?Human Unigene: 284712?Human
Synonyms:	FLJ20300 Antibody BAAT Antibody BAAT_HUMAN Antibody BACAT Antibody BAT Antibody Bile acid CoA: amino acid N-acyltransferase (glycine N-choloyltransferase) Antibody Bile acid CoA:amino acid N acyltransferase Antibody Bile acid Coenzyme A amino acid N acyltransferase glycine N choloyltransferase Antibody Bile acid Coenzyme A: amino acid N acyltransferase Antibody Bile acid-CoA:amino acid N-acyltransferase Antibody Glycine N choloyltransferase Antibody Glycine N-choloyltransferase Antibody Long chain fatty acyl CoA hydrolase Antibody Long-chain fatty-acyl-CoA hydrolase Antibody MGC104432 Antibody
Information:	Target information shown above is from the UniProt Consortium.