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Anti-BAP1 Antibody

品牌：Antibodies

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规格：100µl

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Anti-BAP1 Antibody

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Overview

Name:	Anti-BAP1 Antibody See all BAP1 primary antibodies
Description:	Rabbit polyclonal antibody to BAP1
Specificity:	The antibody detects endogenous levels of total BAP1 protein.
Applications:	WB, IHC
Reactivity:	Human
Immunogen:	Fusion protein corresponding to a region derived from internal residues of human BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	Antigen affinity purification.
Concentration:	1.5mg / ml
Formulation:	Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
Storage:	Store at -20?C

Target

Function:	Deubiquitinating enzyme that plays a key role in chromatin by mediating deubiquitination of histone H2A and HCFC1. Catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1). Does not deubiquitinate monoubiquitinated histone H2B. Acts as a regulator of cell growth by mediating deubiquitination of HCFC1 N-terminal and C-terminal chains, with some specificity toward 'Lys-48'-linked polyubiquitin chains compared to 'Lys-63'-linked polyubiquitin chains. Deubiquitination of HCFC1 does not lead to increase stability of HCFC1. Interferes with the BRCA1 and BARD1 heterodimer activity by inhibiting their ability to mediate ubiquitination and autoubiquitination. It however does not mediate deubiquitination of BRCA1 and BARD1. Able to mediate autodeubiquitination via intramolecular interactions to couteract monoubiquitination at the nuclear localization signal (NLS), thereby protecting it from cytoplasmic sequestration (PubMed:24703950). Acts as a tumor suppressor.
Tissue Specificity:	Highly expressed in testis, placenta and ovary. Expressed in breast.
Involvement in Disease:	Mesothelioma, malignant: An aggressive neoplasm of the serosal lining of the chest. It appears as broad sheets of cells, with some regions containing spindle-shaped, sarcoma-like cells and other regions showing adenomatous patterns. Pleural mesotheliomas have been linked to exposure to asbestos. Tumor predisposition syndrome: A condition characterized by predisposition to develop a variety of tumors, including benign melanocytic tumors as well as several malignant tumors, including uveal melanoma, cutaneous melanoma, malignant mesothelioma on exposure to asbestos, lung adenocarcinoma and meningioma.
Sequence Similarities:	Belongs to the peptidase C12 family. BAP1 subfamily.
Post-Translational Modification:	Ubiquitinated: monoubiquitinated at multiple site of its nuclear localization signal (NLS) BY UBE2O, leading to cytoplasmic retention. Able to mediate autodeubiquitination via intramolecular interactions to couteract cytoplasmic retention.
Cellular Location:	Cytoplasm. Nucleus. Mainly nuclear. Binds to chromatin. Localizes to the cytoplasm when monoubiquitinated by the E2/E3 hybrid ubiquitin-protein ligase UBE2O (PubMed:24703950).
Database Links:	Entrez Gene: 8314?Human Omim: 603089?Human SwissProt: Q92560?Human Unigene: 106674?Human
Synonyms:	BAP 1 Antibody BAP1 Antibody BAP1_HUMAN Antibody BRCA 1 associated protein 1 Antibody BRCA1 associated protein 1 Antibody BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase) Antibody BRCA1-associated protein 1 Antibody Cerebral protein 13 Antibody Cerebral protein 6 Antibody DKFZp686N04275 Antibody FLJ35406 Antibody FLJ37180 Antibody HUCEP 13 Antibody Hucep 6 Antibody HUCEP13 Antibody Hucep6 Antibody KIAA0272 Antibody TPDS Antibody Ubiquitin carboxy terminal hydrolase Antibody Ubiquitin carboxyl terminal hydrolase BAP 1 Antibody Ubiquitin carboxyl terminal hydrolase BAP1 Antibody Ubiquitin carboxyl-terminal hydrolase BAP1 Antibody UCHL2 Antibody
Information:	Target information shown above is from the UniProt Consortium.